NP_036442.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
128,459 Da
NCBI Official Full Name
chromosome-associated kinesin KIF4A
NCBI Official Synonym Full Names
kinesin family member 4A
NCBI Protein Information
chromosome-associated kinesin KIF4A
UniProt Protein Name
Chromosome-associated kinesin KIF4A
UniProt Synonym Protein Names
Chromokinesin-A
UniProt Synonym Gene Names
UniProt Entry Name
KIF4A_HUMAN
NCBI Summary for KIF4A
This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]
UniProt Comments for KIF4A
KIF4A: Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization. Belongs to the kinesin-like protein family. Chromokinesin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: chromosome; cytoplasm; cytosol; kinesin complex; membrane; midbody; nuclear matrix; nucleoplasm; spindle microtubule
Molecular Function: ATP binding; DNA binding; microtubule binding; microtubule motor activity; plus-end-directed microtubule motor activity; protein binding
Biological Process: anterograde axon cargo transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; cytokinesis after mitosis; metabolic process; microtubule-based movement; organelle organization and biogenesis; retrograde vesicle-mediated transport, Golgi to ER; spindle midzone assembly involved in mitosis
Disease: Mental Retardation, X-linked 100
Research Articles on KIF4A
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Pathways associated with KIF4A blocking peptide
Diseases associated with KIF4A blocking peptide
Organs/Tissues associated with KIF4A blocking peptide
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