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Kcnj11 peptide :: Kcnj11 / Kir6.2 Peptide

Scan QR to view Datasheet Catalog #    MBS427002 Kcnj11 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Kcnj11 / Kir6.2, Peptide

 Also Known As   

Kcnj11 / Kir6.2 Immunizing Peptide

 Product Synonym Names    KCNJ11; Kir6.2; potassium inwardly-rectifying channel, subfamily J, member 11; mBIR; AI842722; AW491124; potassium inwardly rectifying channel, subfamily J, member 11; KATP; KATP channel; Kcnj11 / Kir6.2
 Product Gene Name   

Kcnj11 peptide

[Similar Products]
 Product Synonym Gene Name    Kir6.2 [Similar Products]
 Antibody/Peptide Pairs    Kcnj11 / Kir6.2 peptide (MBS427002) is used for blocking the activity of Kcnj11/Kir6.2 antibody (MBS421535)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    ERRARFVSKK GNC
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 Species Reactivity    Human, Mouse, Rat, Dog
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of Kcnj11 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Kcnj11. It may not necessarily be applicable to this product.
 NCBI GI #    6754426
 NCBI GeneID    16514
 NCBI Accession #    NP_034732.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_010602.3 [Other Products]
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 UniProt Secondary Accession #    Q9QX21 [Other Products]
 UniProt Related Accession #    Q61743 [Other Products]
 Molecular Weight    43,562 Da
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 NCBI Official Full Name    ATP-sensitive inward rectifier potassium channel 11 isoform 1
 NCBI Official Synonym Full Names    potassium inwardly rectifying channel, subfamily J, member 11
 NCBI Official Symbol    Kcnj11 [Similar Products]
 NCBI Official Synonym Symbols   
mBIR; Kir6.2
[Similar Products]
 NCBI Protein Information    ATP-sensitive inward rectifier potassium channel 11
 UniProt Protein Name    ATP-sensitive inward rectifier potassium channel 11
 UniProt Synonym Protein Names   
Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11
 Protein Family    ATP-sensitive inward rectifier potassium channel
 UniProt Gene Name    Kcnj11 [Similar Products]
 UniProt Entry Name    KCJ11_MOUSE
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 UniProt Comments for Kcnj11    Kir6.2: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Defects in KCNJ11 are the cause of familial hyperinsulinemic hypoglycemia type 2 (HHF2); also known as persistent hyperinsulinemic hypoglycemia of infancy (PPHI) or congenital hyperinsulinism. HHF is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. It causes nesidioblastosis, a diffuse abnormality of the pancreas in which there is extensive, often disorganized formation of new islets. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur. Defects in KCNJ11 are a cause of diabetes mellitus permanent neonatal (PNDM). PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. Defects in KCNJ11 are the cause of transient neonatal diabetes mellitus type 3 (TNDM3). Neonatal diabetes mellitus, defined as insulin-requiring hyperglycemia within the first month of life, is a rare entity. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. In a significant number of patients with transient neonatal diabetes mellitus, diabetes type 2 appears later in life. The onset and severity of TNDM3 is variable with childhood-onset diabetes, gestational diabetes or adult-onset diabetes described. Defects in KCNJ11 may contribute to non-insulin- dependent diabetes mellitus (NIDDM), also known as diabetes mellitus type 2. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.

Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral

Cellular Component: ATP-sensitive potassium channel complex; axolemma; cell soma; cytosol; endoplasmic reticulum; endosome; integral to membrane; intracellular membrane-bound organelle; membrane; mitochondrion; myelin sheath; nuclear envelope; plasma membrane; sarcolemma; T-tubule; voltage-gated potassium channel complex

Molecular Function: ankyrin binding; ATP binding; ATP-activated inward rectifier potassium channel activity; heat shock protein binding; inward rectifier potassium channel activity; potassium ion binding; protein binding; protein C-terminus binding; voltage-gated ion channel activity; voltage-gated potassium channel activity

Biological Process: glucose metabolic process; ion transport; negative regulation of insulin secretion; neurological system process; potassium ion import; potassium ion transport; regulation of insulin secretion; regulation of membrane potential; response to ATP; response to drug; transport
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 Research Articles on Kcnj11    1. A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium Channels.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Kcnj11 peptidePathways associated with Kcnj11 peptide
 Reference Product  PubMed Publications
 Abcc8 peptide  >303 publications with Kcnj11 and Abcc8
 Kcnj8 peptide  >14 publications with Kcnj11 and Kcnj8
 Abcc9 peptide  >14 publications with Kcnj11 and Abcc9
 Slc2a2 peptide  >12 publications with Kcnj11 and Slc2a2
 Isl1 peptide  >3 publications with Kcnj11 and Isl1
 Foxa2 peptide  >1 publications with Kcnj11 and Foxa2
 Products by Pathway  Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 ATP Sensitive Potassium Channels Pathway antibodies  ATP Sensitive Potassium Channels Pathway Diagram
 Cardiac Conduction Pathway antibodies  Cardiac Conduction Pathway Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Ion Homeostasis Pathway antibodies  Ion Homeostasis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
Diseases associated with Kcnj11 peptideOrgans/Tissues associated with Kcnj11 peptide
 Disease Name  Pubmed Publications
 Diabetes Mellitus Antibodies  >416 publications with Kcnj11 and Diabetes Mellitus
 Diabetes Mellitus, Type 2 Antibodies  >186 publications with Kcnj11 and Diabetes Mellitus, Type 2
 Hypoglycemia Antibodies  >146 publications with Kcnj11 and Hypoglycemia
 Congenital Hyperinsulinism Antibodies  >128 publications with Kcnj11 and Congenital Hyperinsulinism
 Diabetes Mellitus, Type 1 Antibodies  >76 publications with Kcnj11 and Diabetes Mellitus, Type 1
 Hyperglycemia Antibodies  >60 publications with Kcnj11 and Hyperglycemia
 Insulin Resistance Antibodies  >44 publications with Kcnj11 and Insulin Resistance
 Cardiovascular Diseases Antibodies  >36 publications with Kcnj11 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >20 publications with Kcnj11 and Vascular Diseases
 Diabetes Mellitus, Transient Neonatal, 3 Antibodies  >19 publications with Kcnj11 and Diabetes Mellitus, Transient Neonatal, 3
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >102 publications with Kcnj11 and Pancreas
 Heart Antibodies  >37 publications with Kcnj11 and Heart
 Brain Antibodies  >37 publications with Kcnj11 and Brain
 Embryonic Tissue Antibodies  >2 publications with Kcnj11 and Embryonic Tissue
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