NP_849164.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,316 Da
NCBI Official Full Name
ceramide synthase 3 isoform 2
NCBI Official Synonym Full Names
ceramide synthase 3
NCBI Official Synonym Symbols
NCBI Protein Information
ceramide synthase 3
UniProt Protein Name
Ceramide synthase 3
UniProt Synonym Protein Names
Dihydroceramide synthase 3; LAG1 longevity assurance homolog 3
UniProt Synonym Gene Names
UniProt Entry Name
CERS3_HUMAN
NCBI Summary for LASS3
This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
UniProt Comments for LASS3
Lass3: Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18:0 and other middle- to long-chain fatty acyl-CoAs. It is crucial for the synthesis of very long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; EC 2.3.1.24; DNA-binding
Chromosomal Location of Human Ortholog: 15q26.3
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nuclear membrane
Molecular Function: DNA binding; sphingosine N-acyltransferase activity
Biological Process: ceramide biosynthetic process; keratinocyte differentiation; sphingolipid biosynthetic process
Disease: Ichthyosis, Congenital, Autosomal Recessive 9
Research Articles on LASS3
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Pathways associated with LASS3 blocking peptide
Diseases associated with LASS3 blocking peptide
Organs/Tissues associated with LASS3 blocking peptide
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