NP_690000.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
75,599 Da
NCBI Official Full Name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
NCBI Official Synonym Full Names
TGF-beta activated kinase 1/MAP3K7 binding protein 3
NCBI Protein Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
UniProt Protein Name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
UniProt Synonym Protein Names
Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NF-kappa-B-activating protein 1; TAK1-binding protein 3; TAB-3; TGF-beta-activated kinase 1-binding protein 3
UniProt Synonym Gene Names
UniProt Entry Name
TAB3_HUMAN
NCBI Summary for MAP3K7IP3
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for MAP3K7IP3
TAB3: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: Xp21.2
Cellular Component: cytoplasm; cytosol; endosome membrane; nucleoplasm; plasma membrane
Molecular Function: protein binding; zinc ion binding
Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; I-kappaB kinase/NF-kappaB cascade; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; negative regulation of autophagy; stimulatory C-type lectin receptor signaling pathway
Research Articles on MAP3K7IP3
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Pathways associated with MAP3K7IP3 blocking peptide
Diseases associated with MAP3K7IP3 blocking peptide
Organs/Tissues associated with MAP3K7IP3 blocking peptide
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