NP_004979.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
melanoma-associated antigen 1
NCBI Official Synonym Full Names
MAGE family member A1
NCBI Official Synonym Symbols
NCBI Protein Information
melanoma-associated antigen 1
UniProt Protein Name
Melanoma-associated antigen 1
UniProt Synonym Protein Names
Antigen MZ2-E; Cancer/testis antigen 1.1; CT1.1; MAGE-1 antigen
UniProt Synonym Gene Names
NCBI Summary for Mage-1
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]
UniProt Comments for Mage-1
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Research Articles on Mage-1
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Products associated with Mage-1 peptide
Pathways associated with Mage-1 peptide
Diseases associated with Mage-1 peptide
Organs/Tissues associated with Mage-1 peptide
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