NP_063941.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,043 Da
NCBI Official Full Name
melanocortin 3 receptor
NCBI Official Synonym Full Names
melanocortin 3 receptor
NCBI Protein Information
melanocortin receptor 3
UniProt Protein Name
Melanocortin receptor 3
UniProt Synonym Gene Names
UniProt Entry Name
MC3R_HUMAN
NCBI Summary for MC3R
This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008]
UniProt Comments for MC3R
MC3R: Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 20q13.2-q13.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: melanocortin receptor activity; melanocyte stimulating hormone receptor activity; neuropeptide binding; peptide hormone binding; protein binding
Biological Process: circadian regulation of gene expression; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); homoiothermy; locomotor rhythm; positive regulation of cAMP biosynthetic process; regulation of blood pressure; regulation of heart rate; sodium ion homeostasis
Disease: Body Mass Index Quantitative Trait Locus 9; Mycobacterium Tuberculosis, Susceptibility To
Research Articles on MC3R
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Pathways associated with MC3R blocking peptide
Diseases associated with MC3R blocking peptide
Organs/Tissues associated with MC3R blocking peptide
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