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Melt peptide :: Melittin Peptide

Scan QR to view Datasheet Catalog #    MBS659880 Melt peptide
Unit / Price
1 mg  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Melittin (Melt), Peptide

★Popular Item★
 Also Known As   

Melittin

 Product Gene Name   

Melt peptide

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: LG4; NC_007073.3 (9255700..9257194). Location: chromosome: LG4
 3D Structure    ModBase 3D Structure for P01501
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 Host    Synthetic peptide
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 Purity/Purification    96.49%
 Form/Format    Supplied as a lyophilized powder.
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 Sequence (linear)    Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
 Molecular Formula    C131H229N39O31
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 Preparation and Storage    Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of Melt peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for Melt peptide    Molecular Biology; MB-Peptides
NCBI/Uniprot data below describe general gene information for Melt. It may not necessarily be applicable to this product.
 NCBI GI #    58585154
 NCBI GeneID    406130
 NCBI Accession #    NP_001011607.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001011607.1 [Other Products]
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 UniProt Primary Accession #    P01501 [Other Products]
 UniProt Secondary Accession #    P01503 [Other Products]
 UniProt Related Accession #    P01501 [Other Products]
 Molecular Weight    2846.53 [Similar Products]
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 NCBI Official Full Name    melittin
 NCBI Official Synonym Full Names    melittin<
 NCBI Official Symbol    Melt [Similar Products]
 NCBI Official Synonym Symbols   
GB10355
[Similar Products]
 NCBI Protein Information    melittin; allergen Api m 3; allergen Api m III
 UniProt Protein Name    Melittin
 UniProt Synonym Protein Names   
Allergen Api m 3; Allergen Api m III
 Protein Family    Melittin
 UniProt Gene Name    MELT [Similar Products]
 UniProt Entry Name    MEL_APIME
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 UniProt Comments for Melt    Function: Melittin: Main toxin of bee venom with strong hemolytic activity. Forms a pore in the cell membrane by inserting into lipid bilayers in an alpha-helical conformation and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase. It increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange. It acts synergistically with phospholipase A2. Ref.3Melittin-S: 1.4-fold less hemolytic and adopts a less organized secondary structure than melittin. Ref.3

Subunit structure: Monomer and homotetramer.

Subcellular location: Secreted. Target cell membrane. Note: Forms a transmembrane alpha-helix in the target cell membrane. Forms a membrane channel in the prey.

Tissue specificity: Expressed by the venom gland.

Allergenic properties: Causes an allergic reaction in human.

Toxic dose: LC50 is 2.7 µg/ml against killifish. Ref.7

Miscellaneous: N-formyl-melittin major has 80% of the activity of melittin.Melittin: The secretion of this protein into venom follows a seasonal pattern. This variation is synchronized with phospholipase A2 variation, i.e. their production increase in the same months.Melittin-S: The secretion of this protein into venom follows a seasonal pattern, the maximum secretion occurring during the (southern) winter months.

Sequence similarities: Belongs to the melittin family.
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 Research Articles on Melt    1. These findings point to the preservation and, from more aqueous solvent conditions, the formation of an at least partially helical form of melittin in the gas-phase.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Melt peptide
 Reference Product  PubMed Publications
 Pkc peptide  >17 publications with Melt and Pkc
 pla2 peptide  >4 publications with Melt and pla2
 apamin peptide  >3 publications with Melt and apamin
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