P19022
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
N-cadherin
NCBI Official Synonym Full Names
cadherin 2, type 1, N-cadherin (neuronal)
NCBI Protein Information
cadherin-2; N-cadherin 1; neural cadherin; neural-cadherin; OTTHUMP00000066304; OTTHUMP00000067378; cadherin 2, N-cadherin (neuronal); calcium-dependent adhesion protein, neuronal
UniProt Protein Name
Cadherin-2
UniProt Synonym Protein Names
CDw325; Neural cadherin
UniProt Synonym Gene Names
UniProt Entry Name
CADH2_HUMAN
NCBI Summary for CDH2
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq]
UniProt Comments for CDH2
Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density
Subunit structure: Interacts with CDCP1. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway
By similarity. Ref.10
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Sequence similarities: Contains 5 cadherin domains.
Product References and Citations for CDH2 peptide
• Xu, Y. et al. (1997) J. Biol. Chem. 272(21):13463 • Xu, Y. & Carpenter, G. (1999) J. Cell. Bioch. 75:264. • Qi, J. et al. (2006) Mol. Biol. Cell 17(3):1261.
Research Articles on CDH2
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Products associated with CDH2 peptide
Pathways associated with CDH2 peptide
Diseases associated with CDH2 peptide
Organs/Tissues associated with CDH2 peptide
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