NP_443108.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
57,258 Da
NCBI Official Full Name
nucleus accumbens-associated protein 1
NCBI Official Synonym Full Names
nucleus accumbens associated 1
NCBI Official Synonym Symbols
NAC1; BEND8; NAC-1; BTBD30; BTBD14B [Similar Products]
NCBI Protein Information
nucleus accumbens-associated protein 1
UniProt Protein Name
Nucleus accumbens-associated protein 1
UniProt Synonym Protein Names
BTB/POZ domain-containing protein 14B
UniProt Synonym Gene Names
UniProt Entry Name
NACC1_HUMAN
NCBI Summary for BTBD14B
This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012]
UniProt Comments for BTBD14B
NAC1: Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 AND RCOR1. Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: cytoplasm; nuclear body; nucleus
Biological Process: negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; protein homooligomerization; transcription, DNA-dependent
Research Articles on BTBD14B
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Diseases associated with BTBD14B blocking peptide
Organs/Tissues associated with BTBD14B blocking peptide
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