NP_009202.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,190 Da
NCBI Official Full Name
serine/threonine-protein kinase 38
NCBI Official Synonym Full Names
serine/threonine kinase 38
NCBI Official Synonym Symbols
NCBI Protein Information
serine/threonine-protein kinase 38
UniProt Protein Name
Serine/threonine-protein kinase 38
UniProt Synonym Protein Names
NDR1 protein kinase; Nuclear Dbf2-related kinase 1
UniProt Entry Name
STK38_HUMAN
NCBI Summary for STK38
This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
UniProt Comments for STK38
NDR1: is an AGC kinase of the NDR family. An apparent upstream regulator of Myc activity in human B-cell lymphoma. Mediates apoptosis downstream of the tumor suppressor proteins RASSF1A and MST1. Reduced expression of NDR1 results in defective apoptotic responses and a predisposition to develop T cell lymphoma in mice. Activated by binding of S100B which releases autoinhibitory N-lobe interactions. Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, AGC; AGC group; NDR family
Chromosomal Location of Human Ortholog: 6p21
Cellular Component: cytoplasm; nucleus
Molecular Function: ATP binding; magnesium ion binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein serine/threonine kinase activity
Biological Process: negative regulation of MAP kinase activity; peptidyl-serine phosphorylation; protein amino acid phosphorylation; protein modification process
Research Articles on STK38
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Diseases associated with STK38 blocking peptide
Organs/Tissues associated with STK38 blocking peptide
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