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NDRG1 peptide

Scan QR to view Datasheet Catalog #    MBS426596 NDRG1 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NDRG1, Peptide

 Also Known As   

NDRG1 Immunizing Peptide

 Product Synonym Names    NDRG1; N-myc downstream regulated gene 1; CAP43,; CMT4D; DRG1; GC4; HMSNL; NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5; N-myc downstream regulated gene 1 protein; differentiation-related gene 1 protein; nickel-specific induction protein Cap43; protein reg
 Product Gene Name   

NDRG1 peptide

[Similar Products]
 Antibody/Peptide Pairs    NDRG1 peptide (MBS426596) is used for blocking the activity of NDRG1 antibody (MBS420361)
 Antibody/Peptide Pairs    NDRG1 peptide (MBS426596) is used for blocking the activity of NDRG1 antibody (MBS423562)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    GNSAGPKSME VSC
 OMIM    601455
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 Species Reactivity    Human, Mouse, Rat, Dog
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of NDRG1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for NDRG1. It may not necessarily be applicable to this product.
 NCBI GI #    37655183
 NCBI GeneID    10397
 NCBI Accession #    NP_006087.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006096.3 [Other Products]
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 UniProt Secondary Accession #    O15207; Q6IBG2; Q9NYR6; Q9UK29; B3KR80; B7Z446 [Other Products]
 UniProt Related Accession #    Q92597 [Other Products]
 Molecular Weight    33,650 Da
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 NCBI Official Full Name    protein NDRG1 isoform 1
 NCBI Official Synonym Full Names    N-myc downstream regulated 1
 NCBI Official Symbol    NDRG1 [Similar Products]
 NCBI Official Synonym Symbols   
GC4; RTP; DRG1; NDR1; NMSL; TDD5; CAP43; CMT4D; DRG-1; HMSNL; RIT42; TARG1; PROXY1
[Similar Products]
 NCBI Protein Information    protein NDRG1
 UniProt Protein Name    Protein NDRG1
 UniProt Synonym Protein Names   
Differentiation-related gene 1 protein; DRG-1; N-myc downstream-regulated gene 1 protein; Nickel-specific induction protein Cap43; Reducing agents and tunicamycin-responsive protein; RTP; Rit42
 Protein Family    Protein
 UniProt Gene Name    NDRG1 [Similar Products]
 UniProt Synonym Gene Names    CAP43; DRG1; RTP; DRG-1; RTP [Similar Products]
 UniProt Entry Name    NDRG1_HUMAN
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 NCBI Summary for NDRG1    This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
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 UniProt Comments for NDRG1    NDRG1: a hypoxia-inducible anti-apoptotic protein. Promotes proliferation and correlates with invasion, metastasis and poor prognosis in many cancers. Is involved in growth arrest and cell differentiation during development. A ubiquitous Rab4a effector protein that modulates angiogenesis and is involved in vesicular recycling of E-cadherin. Colocalizes with transferrin during the recycling in cells. NDRG1 knockdown delays the recycling rate of transferrin, while its overexpression increases the rate of transferrin recycling. Interacts with SIRT1/p53 signaling to attenuate hypoxic injury in human trophoblasts. Its expression is induced by an elevation of free intracellular calcium ion caused by nickel ion exposure. Highly expressed in placental membranes, prostate, kidney, small intestine, ovary, peripheral nerves and Schwann cells. Defects in NDRG1 are the cause of Charcot-Marie-Tooth disease type 4D (CMT4D).

Protein type: Vesicle; Cell development/differentiation

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: cell-cell adherens junction; centrosome; cytoplasm; cytosol; microtubule; microtubule cytoskeleton; myelin sheath; nucleus; perinuclear region of cytoplasm; plasma membrane; recycling endosome membrane

Molecular Function: cadherin binding; gamma-tubulin binding; microtubule binding; protein binding; Rab GTPase binding

Biological Process: DNA damage response, signal transduction by p53 class mediator; mast cell activation; myelin maintenance in the peripheral nervous system; negative regulation of cell proliferation; regulation of apoptosis; response to metal ion

Disease: Charcot-marie-tooth Disease, Type 4d
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 Research Articles on NDRG1    1. NDRG1 could increase the resistance of neuroblastoma cells to chemotherapeutic drugs, with its positive regulation on drug resistant proteins.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NDRG1 peptidePathways associated with NDRG1 peptide
 Reference Product  PubMed Publications
 MYC peptide  >280 publications with NDRG1 and MYC
 HIF1A peptide  >20 publications with NDRG1 and HIF1A
 MYCN peptide  >15 publications with NDRG1 and MYCN
 PTEN peptide  >10 publications with NDRG1 and PTEN
 TP53 peptide  >6 publications with NDRG1 and TP53
 CD82 peptide  >4 publications with NDRG1 and CD82
 ARNT peptide  >1 publications with NDRG1 and ARNT
 CDH1 peptide  >1 publications with NDRG1 and CDH1
 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 TP53 Regulates Transcription Of Cell Death Genes Pathway antibodies  TP53 Regulates Transcription Of Cell Death Genes Pathway Diagram
 TP53 Regulates Transcription Of Several Additional Cell Death Genes Whose Specific Roles In P53-dependent Apoptosis Remain Uncertain Pathway antibodies  TP53 Regulates Transcription Of Several Additional Cell Death Genes Whose Specific Roles In P53-dependent Apoptosis Remain Uncertain Pathway Diagram
 Transcriptional Regulation By TP53 Pathway antibodies  Transcriptional Regulation By TP53 Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies  Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram
Diseases associated with NDRG1 peptideOrgans/Tissues associated with NDRG1 peptide
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >45 publications with NDRG1 and Neoplasm Metastasis
 Prostatic Neoplasms Antibodies  >31 publications with NDRG1 and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >30 publications with NDRG1 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >18 publications with NDRG1 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >16 publications with NDRG1 and Liver Diseases
 Lung Neoplasms Antibodies  >13 publications with NDRG1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >13 publications with NDRG1 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >13 publications with NDRG1 and Liver Neoplasms
 Disease Models, Animal Antibodies  >10 publications with NDRG1 and Disease Models, Animal
 Glioblastoma Antibodies  >8 publications with NDRG1 and Glioblastoma
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >43 publications with NDRG1 and Prostate
 Nerve Antibodies  >40 publications with NDRG1 and Nerve
 Blood Antibodies  >33 publications with NDRG1 and Blood
 Brain Antibodies  >29 publications with NDRG1 and Brain
 Liver Antibodies  >27 publications with NDRG1 and Liver
 Vascular Antibodies  >23 publications with NDRG1 and Vascular
 Lung Antibodies  >22 publications with NDRG1 and Lung
 Muscle Antibodies  >18 publications with NDRG1 and Muscle
 Lymph Node Antibodies  >15 publications with NDRG1 and Lymph Node
 Bone Antibodies  >15 publications with NDRG1 and Bone
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