NP_001028603.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
119,319 Da
NCBI Official Full Name
NACHT, LRR and PYD domains-containing protein 12
NCBI Official Synonym Full Names
NLR family, pyrin domain containing 12
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 12
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 12
UniProt Synonym Protein Names
Monarch-1; PYRIN-containing APAF1-like protein 7; PYPAF7
UniProt Synonym Gene Names
UniProt Entry Name
NAL12_MOUSE
UniProt Comments for Nlrp12
NLRP12: May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK. Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2). FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold. Belongs to the NLRP family. 5 isoforms of the human protein are produced by alternative splicing.
Cellular Component: cytoplasm; nucleus
Molecular Function: ATP binding; nucleotide binding; protein binding
Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of cytokine secretion; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of inflammatory response; negative regulation of interleukin-1 secretion; negative regulation of interleukin-6 biosynthetic process; negative regulation of protein amino acid autophosphorylation; negative regulation of signal transduction; negative regulation of Toll signaling pathway; positive regulation of MHC class I biosynthetic process; regulation of caspase activity; regulation of I-kappaB kinase/NF-kappaB cascade; release of cytoplasmic sequestered NF-kappaB
Research Articles on Nlrp12
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Diseases associated with Nlrp12 blocking peptide
Organs/Tissues associated with Nlrp12 blocking peptide
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