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NRG3 peptide :: Neuregulin 3 Peptide

Scan QR to view Datasheet Catalog #    MBS426268 NRG3 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neuregulin 3 (NRG3), Peptide

★Popular Item★
 Also Known As   

Neuregulin 3 Immunizing Peptide

 Product Synonym Names    neuregulin 3; HGNC: 7999; NRG3; HRG3; pro-NRG3; Neuregulin 3; Neuregulin 3
 Product Gene Name   

NRG3 peptide

[Similar Products]
 Antibody/Peptide Pairs    Neuregulin 3 peptide (MBS426268) is used for blocking the activity of Neuregulin 3 antibody (MBS421521)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-RNEIQRDS ALTK
 OMIM    605533
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 Species Reactivity    Human, Mouse, Rat, Dog
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of NRG3 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for NRG3. It may not necessarily be applicable to this product.
 NCBI GI #    66730481
 NCBI GeneID    10718
 NCBI Accession #    NP_001010848.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001010848.3 [Other Products]
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 UniProt Secondary Accession #    Q0PEH2; Q5VYH3; A4D7U1 [Other Products]
 UniProt Related Accession #    P56975 [Other Products]
 Molecular Weight    75,031 Da
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 NCBI Official Full Name    pro-neuregulin-3, membrane-bound isoform isoform 1
 NCBI Official Synonym Full Names    neuregulin 3
 NCBI Official Symbol    NRG3 [Similar Products]
 NCBI Official Synonym Symbols   
HRG3; pro-NRG3
[Similar Products]
 NCBI Protein Information    pro-neuregulin-3, membrane-bound isoform
 UniProt Protein Name    Pro-neuregulin-3, membrane-bound isoform
 Protein Family    Pro-neuregulin
 UniProt Gene Name    NRG3 [Similar Products]
 UniProt Synonym Gene Names    Pro-NRG3; NRG-3 [Similar Products]
 UniProt Entry Name    NRG3_HUMAN
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 NCBI Summary for NRG3    This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]
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 UniProt Comments for NRG3    NRG3: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. Belongs to the neuregulin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 10q23.1

Cellular Component: extracellular region; extracellular space; integral to plasma membrane; intracellular

Molecular Function: chemorepellent activity; growth factor activity; receptor binding; receptor tyrosine kinase binding; transmembrane receptor protein tyrosine kinase activator activity

Biological Process: chemorepulsion involved in interneuron migration from the subpallium to the cortex; organ development; pattern specification process; regulation of cell growth; transmembrane receptor protein tyrosine kinase activation (dimerization)
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 Research Articles on NRG3    1. these data suggest that Nrg3/ErbB4 signaling may be an important factor in nicotine dependence.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with NRG3 peptideDiseases associated with NRG3 peptide
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies  Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >29 publications with NRG3 and Schizophrenia
 Nervous System Diseases Antibodies  >8 publications with NRG3 and Nervous System Diseases
 Cognition Disorders Antibodies  >5 publications with NRG3 and Cognition Disorders
 Growth Disorders Antibodies  >3 publications with NRG3 and Growth Disorders
 Cardiovascular Diseases Antibodies  >3 publications with NRG3 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >3 publications with NRG3 and Adenocarcinoma
 Neurologic Manifestations Antibodies  >2 publications with NRG3 and Neurologic Manifestations
 Chromosome Aberrations Antibodies  >2 publications with NRG3 and Chromosome Aberrations
 Male Urogenital Diseases Antibodies  >2 publications with NRG3 and Male Urogenital Diseases
 Necrosis Antibodies  >2 publications with NRG3 and Necrosis
Organs/Tissues associated with NRG3 peptide
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >30 publications with NRG3 and Brain
 Muscle Antibodies  >4 publications with NRG3 and Muscle
 Eye Antibodies  >2 publications with NRG3 and Eye
 Liver Antibodies  >2 publications with NRG3 and Liver
 Skin Antibodies  >1 publications with NRG3 and Skin
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