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Npc1l1 peptide

Scan QR to view Datasheet Catalog #    MBS427595 Npc1l1 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Npc1l1, Peptide

 Also Known As   

Npc1l1 Immunizing Peptide

 Product Synonym Names    Npc1l1; NPC1-like 1; RP23-198N14.2; 9130221N23Rik; Gm243; Niemann-Pick C1-like protein 1; Niemann-Pick disease, type C1; Niemann-Pick disease, type C1-like 1; OTTMUSP00000000725; Npc1l1 (mouse) (aa56-69)
 Product Gene Name   

Npc1l1 peptide

[Similar Products]
 Antibody/Peptide Pairs    Npc1l1 peptide (MBS427595) is used for blocking the activity of Npc1l1 antibody (MBS422866)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Species Reactivity    Mouse, Rat
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of Npc1l1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Npc1l1. It may not necessarily be applicable to this product.
 NCBI GI #    253970442
 NCBI GeneID    237636
 NCBI Accession #    NP_997125.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_207242.2 [Other Products]
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 UniProt Secondary Accession #    Q5SVX1 [Other Products]
 UniProt Related Accession #    Q6T3U4 [Other Products]
 Molecular Weight    147,132 Da
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 NCBI Official Full Name    Niemann-Pick C1-like protein 1
 NCBI Official Synonym Full Names    NPC1-like 1
 NCBI Official Symbol    Npc1l1 [Similar Products]
 NCBI Official Synonym Symbols   
Gm243; 9130221N23Rik
[Similar Products]
 NCBI Protein Information    Niemann-Pick C1-like protein 1
 UniProt Protein Name    Niemann-Pick C1-like protein 1
 Protein Family    Niemann-Pick C1-like protein
 UniProt Gene Name    Npc1l1 [Similar Products]
 UniProt Entry Name    NPCL1_MOUSE
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 UniProt Comments for Npc1l1    NPC1L1: Play a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorbtion. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Interacts with RAB11A, MYO5B and RAB11FIP2. Interaction with RAB11A, MYO5B and RAB11FIP2 is required for proper transport to the plasma membrane upon cholesterol depletion. Expression is decreased in Caco-2 cells upon PPARD activation. Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle. Belongs to the patched family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: brush border membrane; integral to membrane; membrane; plasma membrane

Molecular Function: drug binding; hedgehog receptor activity; lipid transporter activity; myosin V binding; Rab GTPase binding

Biological Process: cholesterol absorption; cholesterol biosynthetic process; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; lipid metabolic process; lipoprotein metabolic process; steroid metabolic process
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 Research Articles on Npc1l1    1. NPC1L1 knockout protects against colitis-associated tumorigenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Npc1l1 peptidePathways associated with Npc1l1 peptide
 Reference Product  PubMed Publications
 Abcg5 peptide  >105 publications with Npc1l1 and Abcg5
 Abcg8 peptide  >79 publications with Npc1l1 and Abcg8
 Abca1 peptide  >47 publications with Npc1l1 and Abca1
 Scarb1 peptide  >20 publications with Npc1l1 and Scarb1
 Srebf2 peptide  >12 publications with Npc1l1 and Srebf2
 Abcg1 peptide  >8 publications with Npc1l1 and Abcg1
 Hnf4a peptide  >4 publications with Npc1l1 and Hnf4a
 Srebf1 peptide  >2 publications with Npc1l1 and Srebf1
 Cdc42 peptide  >1 publications with Npc1l1 and Cdc42
 Ppara peptide  >1 publications with Npc1l1 and Ppara
 Products by Pathway  Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Retinol Metabolism Pathway antibodies  Retinol Metabolism Pathway Diagram
 Trafficking Of Dietary Sterols Pathway antibodies  Trafficking Of Dietary Sterols Pathway Diagram
Organs/Tissues associated with Npc1l1 peptide
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >189 publications with Npc1l1 and Intestine
 Mixed Antibodies  >9 publications with Npc1l1 and Mixed
 Embryonic Tissue Antibodies  >3 publications with Npc1l1 and Embryonic Tissue
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