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ORAI1 peptide :: ORAI1 / CRACM1 Peptide

Scan QR to view Datasheet Catalog #    MBS426284 ORAI1 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ORAI1 / CRACM1, Peptide

 Also Known As   

ORAI1 / CRACM1 Immunizing Peptide

 Product Synonym Names    ORAI1; CRACM1; ORAI calcium release-activated calcium modulator 1; FLJ14466; ORAT1; TMEM142A; calcium release-activated calcium channel protein 1; calcium release-activated calcium modulator 1; transmembrane protein 142A; ORAI1 / CRACM1
 Product Gene Name   

ORAI1 peptide

[Similar Products]
 Product Synonym Gene Name    CRACM1 [Similar Products]
 Antibody/Peptide Pairs    ORAI1 / CRACM1 peptide (MBS426284) is used for blocking the activity of ORAI1/CRACM1 antibody (MBS421654)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-KKQPGQPR PTSKP
 OMIM    610277
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 Species Reactivity    Human, Dog, Pig
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of ORAI1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ORAI1. It may not necessarily be applicable to this product.
 NCBI GI #    38016943
 NCBI GeneID    84876
 NCBI Accession #    NP_116179.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_032790.3 [Other Products]
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 UniProt Secondary Accession #    Q3MHV3; Q6DHX2; Q96BP7; Q96K71 [Other Products]
 UniProt Related Accession #    Q96D31 [Other Products]
 Molecular Weight    25,337 Da
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 NCBI Official Full Name    calcium release-activated calcium channel protein 1
 NCBI Official Synonym Full Names    ORAI calcium release-activated calcium modulator 1
 NCBI Official Symbol    ORAI1 [Similar Products]
 NCBI Official Synonym Symbols   
IMD9; TAM2; ORAT1; CRACM1; TMEM142A
[Similar Products]
 NCBI Protein Information    calcium release-activated calcium channel protein 1
 UniProt Protein Name    Calcium release-activated calcium channel protein 1
 UniProt Synonym Protein Names   
Protein orai-1; Transmembrane protein 142A
 UniProt Gene Name    ORAI1 [Similar Products]
 UniProt Synonym Gene Names    CRACM1; TMEM142A [Similar Products]
 UniProt Entry Name    CRCM1_HUMAN
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 NCBI Summary for ORAI1    The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
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 UniProt Comments for ORAI1    ORAI1: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. Interacts with STIM1 and STIM2. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with EFCAB4B/CRACR2A and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Belongs to the Orai family.

Protein type: Membrane protein, multi-pass; Channel, calcium; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: autophagic vacuole; basolateral plasma membrane; cytoplasmic vesicle; integral to plasma membrane; membrane; protein complex

Molecular Function: calmodulin binding; identical protein binding; protein binding; store-operated calcium channel activity

Biological Process: adaptive immune response; positive regulation of calcium ion transport; regulation of calcium ion transport

Disease: Immunodeficiency 9; Myopathy, Tubular Aggregate, 2
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 Research Articles on ORAI1    1. STIM1 dimers undergo unimolecular coupling to activate and open Oari1 channels. The model predicts that STIM1 dimers may be involved in crosslinking between Orai1 channels with implications for the kinetics and localization of Orai1 channel opening.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ORAI1 peptidePathways associated with ORAI1 peptide
 Reference Product  PubMed Publications
 STIM1 peptide  >768 publications with ORAI1 and STIM1
 TRPC1 peptide  >129 publications with ORAI1 and TRPC1
 STIM2 peptide  >117 publications with ORAI1 and STIM2
 TRPC3 peptide  >43 publications with ORAI1 and TRPC3
 TRPC4 peptide  >26 publications with ORAI1 and TRPC4
 ITPR3 peptide  >3 publications with ORAI1 and ITPR3
 ITPR1 peptide  >3 publications with ORAI1 and ITPR1
 UBQLN1 peptide  >1 publications with ORAI1 and UBQLN1
 Products by Pathway  Pathway Diagram
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 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cardiac Conduction Pathway antibodies  Cardiac Conduction Pathway Diagram
 Elevation Of Cytosolic Ca2+ Levels Pathway antibodies  Elevation Of Cytosolic Ca2+ Levels Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with ORAI1 peptideOrgans/Tissues associated with ORAI1 peptide
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >49 publications with ORAI1 and Inflammation
 Cardiovascular Diseases Antibodies  >39 publications with ORAI1 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >35 publications with ORAI1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >30 publications with ORAI1 and Disease Models, Animal
 Necrosis Antibodies  >22 publications with ORAI1 and Necrosis
 Breast Neoplasms Antibodies  >18 publications with ORAI1 and Breast Neoplasms
 Kidney Diseases Antibodies  >16 publications with ORAI1 and Kidney Diseases
 Hypertension Antibodies  >13 publications with ORAI1 and Hypertension
 Hypertrophy Antibodies  >10 publications with ORAI1 and Hypertrophy
 Hyperplasia Antibodies  >8 publications with ORAI1 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >188 publications with ORAI1 and Blood
 Kidney Antibodies  >46 publications with ORAI1 and Kidney
 Brain Antibodies  >46 publications with ORAI1 and Brain
 Heart Antibodies  >46 publications with ORAI1 and Heart
 Lung Antibodies  >40 publications with ORAI1 and Lung
 Bone Antibodies  >28 publications with ORAI1 and Bone
 Skin Antibodies  >15 publications with ORAI1 and Skin
 Prostate Antibodies  >15 publications with ORAI1 and Prostate
 Salivary Gland Antibodies  >14 publications with ORAI1 and Salivary Gland
 Bone Marrow Antibodies  >13 publications with ORAI1 and Bone Marrow
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