NP_862820.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65,929 Da
NCBI Official Full Name
origin recognition complex subunit 3 isoform 1
NCBI Official Synonym Full Names
origin recognition complex subunit 3
NCBI Protein Information
origin recognition complex subunit 3
UniProt Protein Name
Origin recognition complex subunit 3
UniProt Synonym Protein Names
Origin recognition complex subunit Latheo
UniProt Synonym Gene Names
UniProt Entry Name
ORC3_HUMAN
NCBI Summary for ORC3L
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ORC3L
ORC3L: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Belongs to the ORC3 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 6q14.3-q16.1
Cellular Component: nuclear chromosome, telomeric region; nuclear origin of replication recognition complex; nucleoplasm; origin recognition complex
Molecular Function: DNA replication origin binding; protein binding
Biological Process: DNA replication; G1/S transition of mitotic cell cycle
Research Articles on ORC3L
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Pathways associated with ORC3L blocking peptide
Diseases associated with ORC3L blocking peptide
Organs/Tissues associated with ORC3L blocking peptide
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