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Obestatin, aa1-23 Peptide

Scan QR to view Datasheet Catalog #    MBS659841 Obestatin, aa1-23 peptide
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
 
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 Product Name   

Obestatin, aa1-23, Peptide

 Also Known As   

Obestatin, Mouse, aa1-23 (Appetite-regulating Hormone, Growth Hormone Secretagogue, Growth Hormone-releasing Peptide, Motilin-related Peptide, Protein M46, Ghrelin, GHRL, MTLRP)

 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    F-N-A-P-F- D-V-G-I-K- L-S-G-A-Q- Y-Q-Q-H-G- R-A-L-NH2
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 Purity/Purification    Purified
~95% (HPLC)
 Form/Format    Supplied as a lyophilized powder. Reconstitute with ddH2O.
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 Molecular Formula    C114H174N34O31
 Solubility    Soluble in dH2O
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of Obestatin, aa1-23 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Obestatin, aa1-23 peptide

   Control of appetite involves a number of gastrointestinal hormones that belong to the Ghrelin-motilin ligand family that either stimulate food intake and gastric emptying or inhibit these responses.

Obestatin, a ghrelin-associated peptide, has recently been discovered by searching for orthologs of the human ghrelin gene and after comparison of preproghrelin sequences from 11 mammalian species. In addition to the known ghrelin peptide, which immediately follows the signal peptide, the researchers identified another conserved region. This region was flanked by a potential convertase cleavage site, which originated a putative 23aa peptide, with a flanking conserved glycine residue at the C- terminal, suggesting that it might be amidated.
Interestingly, Des 1-10 Obestatin (C-terminal 11-23aa) - a truncated peptide of obestatin was shown to have a lower binding affinity to its receptor GPR39 as compared to the full length obestatin. GPR39 mRNA is prominently expressed in the ventral hippocampus, specifically the CA1, which is known to project to the basolateral and basomedial amygdaloid nuclei, which also express GPR39 mRNA. Contextual conditioning is disrupted when any of these nuclei are damaged, indicating that activation of the GPR39 system may modulate this response.
Reports that GPR39 is a cognate receptor for Obestatin were recently contradicted warning for more prudent approach to investigation.
 Product Categories/Family for Obestatin, aa1-23 peptide    Molecular Biology; MB-Obesity
 Molecular Weight    2520.76 [Similar Products]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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