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P2RX4 peptide :: P2X4 / P2X4R Peptide

Scan QR to view Datasheet Catalog #    MBS428506 P2RX4 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

P2X4 / P2X4R (P2RX4), Peptide

 Also Known As   

P2X4 / P2X4R Immunizing Peptide

 Product Synonym Names    P2X4; P2X4R; P2RX4; purinergic receptor P2X, ligand-gated ion channel, 4; ATP receptor; ATP-gated cation channel protein; P2X purinoceptor 4; P2X receptor, subunit 4; purinergic receptor P2X ligand-gated ion channel 4; purinergic receptor P2X4; purinocept; P2X4 / P2X4R
 Product Gene Name   

P2RX4 peptide

[Similar Products]
 Product Synonym Gene Name    P2X4; P2X4R [Similar Products]
 Antibody/Peptide Pairs    P2X4 / P2X4R peptide (MBS428506) is used for blocking the activity of P2X4/P2X4R antibody (MBS422225)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-YREKKYKY VEDYEQ
 OMIM    600846
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 Species Reactivity    Human, Mouse, Rat, Dog, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of P2RX4 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for P2RX4. It may not necessarily be applicable to this product.
 NCBI GI #    28416927
 NCBI GeneID    5025
 NCBI Accession #    NP_002551.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002560.2 [Other Products]
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 UniProt Secondary Accession #    O00450; O14722; Q5U089; Q5U090; Q8N4N1; Q9UBG9; E7EPF7; F6RU17 [Other Products]
 UniProt Related Accession #    Q99571 [Other Products]
 Molecular Weight    40,481 Da
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 NCBI Official Full Name    P2X purinoceptor 4 isoform 2
 NCBI Official Synonym Full Names    purinergic receptor P2X 4
 NCBI Official Symbol    P2RX4 [Similar Products]
 NCBI Official Synonym Symbols   
P2X4; P2X4R
[Similar Products]
 NCBI Protein Information    P2X purinoceptor 4
 UniProt Protein Name    P2X purinoceptor 4
 UniProt Synonym Protein Names   
ATP receptor; Purinergic receptor
 Protein Family    P2X purinoceptor
 UniProt Gene Name    P2RX4 [Similar Products]
 UniProt Synonym Gene Names    P2X4 [Similar Products]
 UniProt Entry Name    P2RX4_HUMAN
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 NCBI Summary for P2RX4    The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
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 UniProt Comments for P2RX4    P2X4: Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. Belongs to the P2X receptor family.

Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q24.32

Cellular Component: cell junction; cell soma; dendritic spine; integral to nuclear inner membrane; integral to plasma membrane; lysosomal membrane; membrane; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; terminal button

Molecular Function: ATP binding; ATP-gated cation channel activity; cadherin binding; copper ion binding; drug binding; protein binding; protein homodimerization activity; purinergic nucleotide receptor activity; receptor binding; zinc ion binding

Biological Process: blood coagulation; endothelial cell activation; generation of action potential; membrane depolarization; positive regulation of calcium ion transport; positive regulation of calcium-mediated signaling; positive regulation of nitric oxide biosynthetic process; positive regulation of prostaglandin secretion; protein homooligomerization; regulation of blood pressure; regulation of sodium ion transport; response to ATP; sensory perception of pain; signal transduction; tissue homeostasis; transport
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 Research Articles on P2RX4    1. Fndings support role for P2X7 and P2X4 coupled to induction of inflammatory molecules in modulating high glucose and palmitate-induced endothelial cell activation and dysfunction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with P2RX4 peptideDiseases associated with P2RX4 peptide
 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Elevation Of Cytosolic Ca2+ Levels Pathway antibodies  Elevation Of Cytosolic Ca2+ Levels Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Platelet Calcium Homeostasis Pathway antibodies  Platelet Calcium Homeostasis Pathway Diagram
 Platelet Homeostasis Pathway antibodies  Platelet Homeostasis Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >16 publications with P2RX4 and Inflammation
 Disease Models, Animal Antibodies  >14 publications with P2RX4 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >12 publications with P2RX4 and Cardiovascular Diseases
 Heart Diseases Antibodies  >8 publications with P2RX4 and Heart Diseases
 Hypertension Antibodies  >7 publications with P2RX4 and Hypertension
 Necrosis Antibodies  >5 publications with P2RX4 and Necrosis
 Liver Diseases Antibodies  >4 publications with P2RX4 and Liver Diseases
 Immune System Diseases Antibodies  >4 publications with P2RX4 and Immune System Diseases
 Hypertrophy Antibodies  >3 publications with P2RX4 and Hypertrophy
 Liver Neoplasms Antibodies  >3 publications with P2RX4 and Liver Neoplasms
Organs/Tissues associated with P2RX4 peptide
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >64 publications with P2RX4 and Brain
 Kidney Antibodies  >21 publications with P2RX4 and Kidney
 Muscle Antibodies  >21 publications with P2RX4 and Muscle
 Heart Antibodies  >21 publications with P2RX4 and Heart
 Blood Antibodies  >20 publications with P2RX4 and Blood
 Bone Antibodies  >11 publications with P2RX4 and Bone
 Ganglia Antibodies  >8 publications with P2RX4 and Ganglia
 Mouth Antibodies  >8 publications with P2RX4 and Mouth
 Lung Antibodies  >6 publications with P2RX4 and Lung
 Eye Antibodies  >6 publications with P2RX4 and Eye
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