CAA41922.1
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
p55 tumor necrosis factor receptor
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 1a
NCBI Official Synonym Symbols
FPF; p55; TNF-R; TNFAR; TNFRI; Tnfr1; p55-R; CD120a; TNF-R1; TNFR60; Tnfr-2; TNF-R-I; TNF-R55; TNFRp55; TNF-alphaR1; TNFalpha-R1 [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 1A
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 1A
UniProt Synonym Protein Names
Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD_antigen: CD120a
UniProt Synonym Gene Names
NCBI Summary for P55-TNFR
This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mice lacking a functional copy of this gene exhibit impaired immune function. [provided by RefSeq, Sep 2016]
UniProt Comments for P55-TNFR
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis ().
Research Articles on P55-TNFR
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Products associated with P55-TNFR peptide
Pathways associated with P55-TNFR peptide
Diseases associated with P55-TNFR peptide
Organs/Tissues associated with P55-TNFR peptide
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