Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Peptide rightarrow SERPINE1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • N-acetylprocainamide Antibody
 • Aquaporin-4 (AQP4) Recombinant Protein
 • ATP5B Antibody
 • POC1A Antibody
 • HIV-1 p66, Strain IIIB Antibody
 • Heat Shock Protein 60 (HSP60) ELISA Kit
 • Amyloid precursor protein fragment C99 (APP C99) ELISA Kit
 • AID (AICDA) Antibody
 • Complement 3a (C3a) ELISA Kit
 • Sterol Regulatory Element Binding Transcription Factor 1 (SR... Recombinant Protein
 • CD2 Recombinant Protein
 • Carcinoembryonic Antigen (CEA) ELISA Kit
 • C-C motif chemokine 20 (CCL20) Recombinant Protein
 • A Disintegrin And Metalloprotease 9 (ADAM9) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

SERPINE1 peptide :: PAI1 / SERPINE1 Peptide

Scan QR to view Datasheet Catalog #    MBS425570 SERPINE1 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PAI1 / SERPINE1, Peptide

 Also Known As   

PAI1 / SERPINE1 Immunizing Peptide

 Product Synonym Names    SERPINE1; PAI1; PAI; PAI-1; PLANH1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; plasminogen activator inhibitor, type I; serpin peptidase inhibitor, clade E (nexin, plasminogen activator in; PAI1 / SERPINE1
 Product Gene Name   

SERPINE1 peptide

[Similar Products]
 Product Synonym Gene Name    PAI1 [Similar Products]
 Antibody/Peptide Pairs    PAI1 / SERPINE1 peptide (MBS425570) is used for blocking the activity of PAI1/SERPINE1 antibody (MBS420848)
 Antibody/Peptide Pairs    PAI1 / SERPINE1 peptide (MBS425570) is used for blocking the activity of PAI1/SERPINE1 antibody (MBS423528)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    C-GFKIDDKG MAPALRH
 OMIM    173360
Section Bar
 Species Reactivity    Human, Dog
Section Bar
 Form/Format    100ug of dried peptide
Section Bar
Section Bar
 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of SERPINE1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for SERPINE1. It may not necessarily be applicable to this product.
 NCBI GI #    10835159
 NCBI GeneID    5054
 NCBI Accession #    NP_000593.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000602.4 [Other Products]
Section Bar
 UniProt Secondary Accession #    B7Z4S0; F8WD53 [Other Products]
 UniProt Related Accession #    P05121 [Other Products]
 Molecular Weight    43,404 Da
Table BarTOPTable Bar
 NCBI Official Full Name    plasminogen activator inhibitor 1
 NCBI Official Synonym Full Names    serpin family E member 1
 NCBI Official Symbol    SERPINE1 [Similar Products]
 NCBI Official Synonym Symbols   
PAI; PAI1; PAI-1; PLANH1
[Similar Products]
 NCBI Protein Information    plasminogen activator inhibitor 1
 UniProt Protein Name    Plasminogen activator inhibitor 1
 UniProt Synonym Protein Names   
Endothelial plasminogen activator inhibitor; Serpin E1
 Protein Family    Plasminogen activator inhibitor
 UniProt Gene Name    SERPINE1 [Similar Products]
 UniProt Synonym Gene Names    PAI1; PLANH1; PAI; PAI-1 [Similar Products]
 UniProt Entry Name    PAI1_HUMAN
Section Bar
 NCBI Summary for SERPINE1    This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Section Bar
 UniProt Comments for SERPINE1    SERPINE1: a secreted protein that acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Belongs to the serpin family. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Plasma levels of PAI-1 and VCAM-1 together may be useful in predicting post-operative recurrence in patients with colorectal cancer.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: extracellular matrix; extracellular region; extracellular space; plasma membrane

Molecular Function: protease binding; protein binding; receptor binding; serine-type endopeptidase inhibitor activity

Biological Process: angiogenesis; chronological cell aging; circadian rhythm; defense response to Gram-negative bacterium; extracellular matrix organization and biogenesis; fibrinolysis; negative regulation of blood coagulation; negative regulation of cell adhesion mediated by integrin; negative regulation of cell migration; negative regulation of fibrinolysis; negative regulation of smooth muscle cell migration; platelet degranulation; positive regulation of angiogenesis; positive regulation of blood coagulation; positive regulation of inflammatory response; positive regulation of interleukin-8 production; positive regulation of receptor-mediated endocytosis; positive regulation of transcription from RNA polymerase II promoter; regulation of receptor activity

Disease: Plasminogen Activator Inhibitor-1 Deficiency
Table BarTOPTable Bar
 Research Articles on SERPINE1    1. Severe septic patients with the 4G/4G genotype had higher plasma PAI-1 concentrations and higher risk of death than those with 4G/5G or 5G/5G genotypes.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with SERPINE1 peptidePathways associated with SERPINE1 peptide
 Reference Product  PubMed Publications
 TGFB1 peptide  >60 publications with SERPINE1 and TGFB1
 SMAD3 peptide  >32 publications with SERPINE1 and SMAD3
 PLAUR peptide  >25 publications with SERPINE1 and PLAUR
 TP53 peptide  >19 publications with SERPINE1 and TP53
 PLAU peptide  >14 publications with SERPINE1 and PLAU
 PLAT peptide  >12 publications with SERPINE1 and PLAT
 SMAD4 peptide  >9 publications with SERPINE1 and SMAD4
 VTN peptide  >1 publications with SERPINE1 and VTN
 PLG peptide  >1 publications with SERPINE1 and PLG
 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
Diseases associated with SERPINE1 peptideOrgans/Tissues associated with SERPINE1 peptide
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >321 publications with SERPINE1 and Cardiovascular Diseases
 Inflammation Antibodies  >157 publications with SERPINE1 and Inflammation
 Thrombosis Antibodies  >127 publications with SERPINE1 and Thrombosis
 Obesity Antibodies  >96 publications with SERPINE1 and Obesity
 Heart Diseases Antibodies  >89 publications with SERPINE1 and Heart Diseases
 Necrosis Antibodies  >85 publications with SERPINE1 and Necrosis
 Atherosclerosis Antibodies  >84 publications with SERPINE1 and Atherosclerosis
 Fibrosis Antibodies  >82 publications with SERPINE1 and Fibrosis
 Nervous System Diseases Antibodies  >71 publications with SERPINE1 and Nervous System Diseases
 Hypertension Antibodies  >49 publications with SERPINE1 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >491 publications with SERPINE1 and Blood
 Vascular Antibodies  >231 publications with SERPINE1 and Vascular
 Lung Antibodies  >68 publications with SERPINE1 and Lung
 Connective Tissue Antibodies  >64 publications with SERPINE1 and Connective Tissue
 Heart Antibodies  >61 publications with SERPINE1 and Heart
 Liver Antibodies  >60 publications with SERPINE1 and Liver
 Kidney Antibodies  >48 publications with SERPINE1 and Kidney
 Adipose Tissue Antibodies  >47 publications with SERPINE1 and Adipose Tissue
 Muscle Antibodies  >45 publications with SERPINE1 and Muscle
 Brain Antibodies  >43 publications with SERPINE1 and Brain
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions