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PAM peptide :: PAM / PAL Peptide

Scan QR to view Datasheet Catalog #    MBS425351 PAM peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PAM / PAL, Peptide

 Also Known As   

PAM / PAL Immunizing Peptide

 Product Synonym Names    PAM; PAL; peptidylglycine alpha-amidating monooxygenase; PHM; pancreatic peptidylglycine alpha-amidating monooxygenase; peptidyl alpha-amidating enzyme; peptidyl-alpha-hydroxyglycine alpha-amidating lyase; peptidylglycine 2-hydroxylase; peptidylglycine a; PAM / PAL
 Product Gene Name   

PAM peptide

[Similar Products]
 Product Synonym Gene Name    PAL [Similar Products]
 Antibody/Peptide Pairs    PAM / PAL peptide (MBS425351) is used for blocking the activity of PAM/PAL antibody (MBS421605)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-DQEKEDDG SESEE
 OMIM    170270
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 Species Reactivity    Human
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of PAM peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for PAM. It may not necessarily be applicable to this product.
 NCBI GI #    21070984
 NCBI GeneID    5066
 NCBI Accession #    NP_000910.2 [Other Products]
 NCBI Related Accession #    NP_620121.1; NP_620176.1; NP_620177.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000919.3 [Other Products]
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 UniProt Secondary Accession #    O43211; O95080; Q16252; Q16253; Q54A45; Q86U53; Q8WVC7; Q9UCG0; A6NMR0; A8K293 [Other Products]
 UniProt Related Accession #    P19021 [Other Products]
 Molecular Weight    106,276 Da
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 NCBI Official Full Name    peptidyl-glycine alpha-amidating monooxygenase isoform a
 NCBI Official Synonym Full Names    peptidylglycine alpha-amidating monooxygenase
 NCBI Official Symbol    PAM [Similar Products]
 NCBI Official Synonym Symbols   
PAL; PHM
[Similar Products]
 NCBI Protein Information    peptidyl-glycine alpha-amidating monooxygenase
 UniProt Protein Name    Peptidyl-glycine alpha-amidating monooxygenase
 UniProt Synonym Protein Names   
Peptidylglycine alpha-hydroxylating monooxygenase (EC:1.14.17.3); PHMPeptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC:4.3.2.5)Alternative name(s):Peptidylamidoglycolate lyase; PAL
 Protein Family    Phenylalanine aminomutase
 UniProt Gene Name    PAM [Similar Products]
 UniProt Synonym Gene Names    PAM; PHM; PAL [Similar Products]
 UniProt Entry Name    AMD_HUMAN
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 NCBI Summary for PAM    This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
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 UniProt Comments for PAM    PAM: Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 1.14.17.3; Vesicle; EC 4.3.2.5; Lyase; Oxidoreductase

Chromosomal Location of Human Ortholog: 5q14-q21

Cellular Component: cell surface; extracellular space; integral to membrane; membrane; neuron projection; perikaryon; perinuclear region of cytoplasm; plasma membrane; secretory granule membrane; trans-Golgi network

Molecular Function: calcium ion binding; copper ion binding; L-ascorbic acid binding; peptidylamidoglycolate lyase activity; peptidylglycine monooxygenase activity; protein binding; protein kinase binding; zinc ion binding

Biological Process: central nervous system development; heart development; lactation; limb development; long-chain fatty acid metabolic process; maternal process involved in pregnancy; odontogenesis; ovulation cycle process; peptide amidation; protein amino acid amidation; protein homooligomerization; regulation of actin cytoskeleton organization and biogenesis; regulation of protein secretion; regulation of transcription from RNA polymerase II promoter; response to copper ion; response to drug; response to estradiol stimulus; response to glucocorticoid stimulus; response to hypoxia; response to pH; toxin metabolic process
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 Research Articles on PAM    1. Oxygen Sensitivity of the Peptidylglycine alpha-Amidating Monooxygenase (PAM) in Neuroendocrine Cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PAM peptideDiseases associated with PAM peptide
 Reference Product  PubMed Publications
 MYC peptide  >36 publications with PAM and MYC
 POMC peptide  >27 publications with PAM and POMC
 UBC peptide  >6 publications with PAM and UBC
 UHMK1 peptide  >5 publications with PAM and UHMK1
 KALRN peptide  >1 publications with PAM and KALRN
 RASSF9 peptide  >1 publications with PAM and RASSF9
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >545 publications with PAM and Nervous System Diseases
 Brain Diseases Antibodies  >281 publications with PAM and Brain Diseases
 Inflammation Antibodies  >279 publications with PAM and Inflammation
 Poisoning Antibodies  >276 publications with PAM and Poisoning
 Necrosis Antibodies  >234 publications with PAM and Necrosis
 Disease Models, Animal Antibodies  >194 publications with PAM and Disease Models, Animal
 Breast Neoplasms Antibodies  >147 publications with PAM and Breast Neoplasms
 Heart Diseases Antibodies  >138 publications with PAM and Heart Diseases
 Neoplasms, Experimental Antibodies  >117 publications with PAM and Neoplasms, Experimental
 Kidney Diseases Antibodies  >88 publications with PAM and Kidney Diseases
Organs/Tissues associated with PAM peptide
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1315 publications with PAM and Blood
 Brain Antibodies  >573 publications with PAM and Brain
 Lung Antibodies  >426 publications with PAM and Lung
 Bone Antibodies  >320 publications with PAM and Bone
 Vascular Antibodies  >242 publications with PAM and Vascular
 Heart Antibodies  >237 publications with PAM and Heart
 Skin Antibodies  >234 publications with PAM and Skin
 Nerve Antibodies  >222 publications with PAM and Nerve
 Muscle Antibodies  >220 publications with PAM and Muscle
 Kidney Antibodies  >181 publications with PAM and Kidney
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