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PCK2 peptide :: PCK2 / PEPCK-M Peptide

Scan QR to view Datasheet Catalog #    MBS426107 PCK2 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PCK2 / PEPCK-M, Peptide

 Also Known As   

PCK2 / PEPCK-M Immunizing Peptide

 Product Synonym Names    PCK2; PEPCK-M; phosphoenolpyruvate carboxykinase 2 (mitochondrial); HGNC: 8725; PEPCK; PEPCK2; PEP carboxykinase; mitochondrial phosphoenolpyruvate carboxykinase 2; phosphoenolpyruvate carboxylase; phosphopyruvate carboxylase; PCK2 / PEPCK-M
 Product Gene Name   

PCK2 peptide

[Similar Products]
 Product Synonym Gene Name    PEPCK-M [Similar Products]
 Antibody/Peptide Pairs    PCK2 / PEPCK-M peptide (MBS426107) is used for blocking the activity of PCK2/PEPCK-M antibody (MBS420663)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    KPWKPGDKEP CAH
 OMIM    261650
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 Species Reactivity    Human, Mouse, Rat, Dog, Pig, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of PCK2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for PCK2. It may not necessarily be applicable to this product.
 NCBI GI #    66346721
 NCBI GeneID    5106
 NCBI Accession #    NP_004554.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004563.2 [Other Products]
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 UniProt Secondary Accession #    O43253; Q86U01; Q9BV62 [Other Products]
 UniProt Related Accession #    Q16822 [Other Products]
 Molecular Weight    47,564 Da
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 NCBI Official Full Name    phosphoenolpyruvate carboxykinase
 NCBI Official Synonym Full Names    phosphoenolpyruvate carboxykinase 2, mitochondrial
 NCBI Official Symbol    PCK2 [Similar Products]
 NCBI Official Synonym Symbols   
PEPCK; PEPCK2; PEPCK-M
[Similar Products]
 NCBI Protein Information    phosphoenolpyruvate carboxykinase [GTP], mitochondrial
 UniProt Protein Name    Phosphoenolpyruvate carboxykinase [GTP], mitochondrial
 Protein Family    Protein kinase
 UniProt Gene Name    PCK2 [Similar Products]
 UniProt Synonym Gene Names    PEPCK2; PEPCK-M [Similar Products]
 UniProt Entry Name    PCKGM_HUMAN
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 NCBI Summary for PCK2    This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]
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 UniProt Comments for PCK2    PCK2: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Monomer. Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - pyruvate; Lyase; Mitochondrial; Carbohydrate Metabolism - citrate (TCA) cycle; EC 4.1.1.32; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Kinase, other

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: GTP binding; metal ion binding; phosphoenolpyruvate carboxykinase (GTP) activity; phosphoenolpyruvate carboxykinase activity; protein binding

Biological Process: gluconeogenesis

Disease: Phosphoenolpyruvate Carboxykinase Deficiency, Mitochondrial
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 Research Articles on PCK2    1. Results indicate that PEPCK promotes tumor growth by increasing glucose and glutamine metabolism, increases anabolic metabolism and promotes mTORC1 activity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PCK2 peptideDiseases associated with PCK2 peptide
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >8 publications with PCK2 and Fatty Liver
 Liver Diseases Antibodies  >7 publications with PCK2 and Liver Diseases
 Liver Neoplasms Antibodies  >4 publications with PCK2 and Liver Neoplasms
 Hepatitis Antibodies  >4 publications with PCK2 and Hepatitis
 Carcinoma, Hepatocellular Antibodies  >4 publications with PCK2 and Carcinoma, Hepatocellular
 Adenocarcinoma Antibodies  >3 publications with PCK2 and Adenocarcinoma
 Lung Neoplasms Antibodies  >3 publications with PCK2 and Lung Neoplasms
 Inflammation Antibodies  >2 publications with PCK2 and Inflammation
 Necrosis Antibodies  >2 publications with PCK2 and Necrosis
 Disease Models, Animal Antibodies  >2 publications with PCK2 and Disease Models, Animal
Organs/Tissues associated with PCK2 peptide
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >28 publications with PCK2 and Liver
 Blood Antibodies  >18 publications with PCK2 and Blood
 Adipose Tissue Antibodies  >9 publications with PCK2 and Adipose Tissue
 Muscle Antibodies  >6 publications with PCK2 and Muscle
 Connective Tissue Antibodies  >5 publications with PCK2 and Connective Tissue
 Kidney Antibodies  >5 publications with PCK2 and Kidney
 Embryonic Tissue Antibodies  >4 publications with PCK2 and Embryonic Tissue
 Lung Antibodies  >3 publications with PCK2 and Lung
 Pancreas Antibodies  >3 publications with PCK2 and Pancreas
 Vascular Antibodies  >2 publications with PCK2 and Vascular
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