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PXMP3 peptide :: PEX2 / PXMP3 Peptide

Scan QR to view Datasheet Catalog #    MBS427305 PXMP3 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PEX2 / PXMP3, Peptide

 Also Known As   

PEX2 / PXMP3 Immunizing Peptide

 Product Synonym Names    PXMP3; peroxisomal membrane protein 3, 35kDa; PAF-1; PAF1; PEX2; PMP3; PMP35; RNF72; RING finger protein 72; peroxin 2; peroxin-2; peroxisome assembly factor-1; PEX2 / PXMP3
 Product Gene Name   

PXMP3 peptide

[Similar Products]
 Product Synonym Gene Name    PEX2 [Similar Products]
 Antibody/Peptide Pairs    PEX2 / PXMP3 peptide (MBS427305) is used for blocking the activity of PEX2/PXMP3 antibody (MBS422386)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-NATVGQSV LNIKYKN
 OMIM    170993
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 Species Reactivity    Human, Mouse, Rat, Dog, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of PXMP3 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for PXMP3. It may not necessarily be applicable to this product.
 NCBI GI #    4506343
 NCBI GeneID    5828
 NCBI Accession #    NP_000309.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000318.2 [Other Products]
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 UniProt Secondary Accession #    Q567S6; Q9BW41 [Other Products]
 UniProt Related Accession #    P28328 [Other Products]
 Molecular Weight    34,843 Da
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 NCBI Official Full Name    peroxisome biogenesis factor 2
 NCBI Official Synonym Full Names    peroxisomal biogenesis factor 2
 NCBI Official Symbol    PEX2 [Similar Products]
 NCBI Official Synonym Symbols   
PAF1; PMP3; ZWS3; PBD5A; PBD5B; PMP35; PXMP3; RNF72
[Similar Products]
 NCBI Protein Information    peroxisome biogenesis factor 2
 UniProt Protein Name    Peroxisome biogenesis factor 2
 UniProt Synonym Protein Names   
35 kDa peroxisomal membrane protein; Peroxin-2; Peroxisomal membrane protein 3; Peroxisome assembly factor 1; PAF-1; RING finger protein 72
 UniProt Gene Name    PEX2 [Similar Products]
 UniProt Synonym Gene Names    PAF1; PMP3; PMP35; PXMP3; RNF72; PAF-1 [Similar Products]
 UniProt Entry Name    PEX2_HUMAN
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 NCBI Summary for PXMP3    This gene encodes an integral peroxisomal membrane protein required for peroxisome biogenesis. The protein is thought to be involved in peroxisomal matrix protein import. Mutations in this gene result in one form of Zellweger syndrome and infantile Refsum disease. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PXMP3    PXMP3: Somewhat implicated in the biogenesis of peroxisomes. Defects in PEX2 are the cause of peroxisome biogenesis disorder complementation group 5 (PBD-CG5); also known as PBD-CGF. PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum. The PBD group is genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Defects in PEX2 are a cause of Zellweger syndrome (ZWS). ZWS is a fatal peroxisome biogenesis disorder characterized by dysmorphic facial features, hepatomegaly, ocular abnormalities, renal cysts, hearing impairment, profound psychomotor retardation, severe hypotonia and neonatal seizures. Death occurs within the first year of life. Defects in PEX2 are a cause of infantile Refsum disease (IRD). IRD is a mild peroxisome biogenesis disorder (PBD). Clinical features include early onset, mental retardation, minor facial dysmorphism, retinopathy, sensorineural hearing deficit, hepatomegaly, osteoporosis, failure to thrive, and hypocholesterolemia. The biochemical abnormalities include accumulation of phytanic acid, very long chain fatty acids (VLCFA), di- and trihydroxycholestanoic acid and pipecolic acid. Belongs to the pex2/pex10/pex12 family.

Protein type: Ubiquitin conjugating system; Membrane protein, multi-pass; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8q21.1

Cellular Component: integral to peroxisomal membrane; membrane; peroxisomal membrane

Molecular Function: protein binding; zinc ion binding

Biological Process: fatty acid beta-oxidation; negative regulation of epithelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of transcription from RNA polymerase II promoter; peroxisome organization and biogenesis; protein destabilization; protein import into peroxisome matrix; very-long-chain fatty acid metabolic process

Disease: Peroxisome Biogenesis Disorder 5a (zellweger); Peroxisome Biogenesis Disorder 5b
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 Research Articles on PXMP3    1. the carrier frequencies for two PEX2 mutations causative of the severe Zellweger syndrome spectrum phenotype in Ashkenazi Jews
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PXMP3 peptidePathways associated with PXMP3 peptide
 Reference Product  PubMed Publications
 PEX5 peptide  >29 publications with PXMP3 and PEX5
 PEX12 peptide  >26 publications with PXMP3 and PEX12
 PEX10 peptide  >25 publications with PXMP3 and PEX10
 PEX13 peptide  >12 publications with PXMP3 and PEX13
 PEX14 peptide  >10 publications with PXMP3 and PEX14
 PEX19 peptide  >8 publications with PXMP3 and PEX19
 Products by Pathway  Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
Diseases associated with PXMP3 peptideOrgans/Tissues associated with PXMP3 peptide
 Disease Name  Pubmed Publications
 Zellweger Syndrome Antibodies  >26 publications with PXMP3 and Zellweger Syndrome
 Peroxisome biogenesis disorders Antibodies  >21 publications with PXMP3 and Peroxisome biogenesis disorders
 Liver Diseases Antibodies  >19 publications with PXMP3 and Liver Diseases
 Brain Diseases Antibodies  >18 publications with PXMP3 and Brain Diseases
 Abnormalities, Multiple Antibodies  >17 publications with PXMP3 and Abnormalities, Multiple
 Kidney Diseases Antibodies  >17 publications with PXMP3 and Kidney Diseases
 Refsum Disease, Infantile Antibodies  >8 publications with PXMP3 and Refsum Disease, Infantile
 Fatty Liver Antibodies  >3 publications with PXMP3 and Fatty Liver
 Embryo Loss Antibodies  >1 publications with PXMP3 and Embryo Loss
 Atrophy Antibodies  >1 publications with PXMP3 and Atrophy
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >16 publications with PXMP3 and Ovary
 Liver Antibodies  >13 publications with PXMP3 and Liver
 Blood Antibodies  >9 publications with PXMP3 and Blood
 Brain Antibodies  >9 publications with PXMP3 and Brain
 Skin Antibodies  >4 publications with PXMP3 and Skin
 Kidney Antibodies  >2 publications with PXMP3 and Kidney
 Nerve Antibodies  >2 publications with PXMP3 and Nerve
 Muscle Antibodies  >2 publications with PXMP3 and Muscle
 Heart Antibodies  >2 publications with PXMP3 and Heart
 Uterus Antibodies  >1 publications with PXMP3 and Uterus
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