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PI3K peptide

Scan QR to view Datasheet Catalog #    MBS843662 PI3K peptide
Unit / Price
0.05 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PI3K, Peptide

 Also Known As   

PI3K Blocking Peptide

 Product Gene Name   

PI3K peptide

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Form/Format    50 ug (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Appearance: Colorless liquid
 Concentration    0.5 mg/ml (lot specific)
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 Handling    The peptide solution should be gently mixed before use.
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 Preparation and Storage    At -20 degree C
Shelf Life: 12 months
 Other Notes    Small volumes of PI3K peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for PI3K peptide   

Western Blot (WB)

 Application Notes for PI3K peptide    The peptide is used for blocking the antibody activity of P13 kinase. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37 degree C.
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NCBI/Uniprot data below describe general gene information for PI3K. It may not necessarily be applicable to this product.
 NCBI GI #    254540080
 NCBI GeneID    18706
 NCBI Accession #    NP_032865 [Other Products]
 NCBI GenBank Nucleotide #    NM_008839.2 [Other Products]
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 UniProt Secondary Accession #    Q0VGQ5 [Other Products]
 UniProt Related Accession #    P42337 [Other Products]
 Molecular Weight    124,412 Da
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 NCBI Official Full Name    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
 NCBI Official Synonym Full Names    phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
 NCBI Official Symbol    Pik3ca [Similar Products]
 NCBI Official Synonym Symbols   
p110; caPI3K; p110alpha; 6330412C24Rik
[Similar Products]
 NCBI Protein Information    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
 UniProt Protein Name    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
 UniProt Synonym Protein Names   
Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA (EC:2.7.11.1)
 UniProt Gene Name    Pik3ca [Similar Products]
 UniProt Synonym Gene Names    PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha [Similar Products]
 UniProt Entry Name    PK3CA_MOUSE
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 UniProt Comments for PI3K    PIK3CA: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the PDPK1- AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Heterodimer of a catalytic subunit PIK3CA and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interacts with IRS1 in nuclear extracts. Interacts with RUFY3. Interacts with RASD2. Interacts with APPL1. Interacts with HRAS1 and KRAS. Interaction with HRAS1/KRAS is required for PI3K pathway signaling and cell proliferation stimulated by EGF and FGF2. Belongs to the PI3/PI4-kinase family.

Protein type: EC 2.7.1.153; Motility/polarity/chemotaxis; EC 2.7.11.1; Carbohydrate Metabolism - inositol phosphate; Kinase, lipid; Oncoprotein

Cellular Component: lamellipodium; plasma membrane; intracellular; phosphoinositide 3-kinase complex

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity; insulin receptor substrate binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; phosphotransferase activity, alcohol group as acceptor; protein kinase activator activity; phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding

Biological Process: phosphoinositide-mediated signaling; phosphoinositide phosphorylation; positive regulation of protein kinase activity; protein kinase B signaling cascade; regulation of multicellular organism growth; glucose metabolic process; angiogenesis; negative regulation of neuron apoptosis; phosphorylation; protein amino acid phosphorylation; positive regulation of peptidyl-serine phosphorylation
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 Research Articles on PI3K    1. expression of the Pik3ca(H1047R) mutation throughout the body resulted in a dramatic increase in body weight within 3 weeks of induction, which was associated with increased organ size rather than adiposity
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PI3K peptideDiseases associated with PI3K peptide
 Reference Product  PubMed Publications
 Kras peptide  >767 publications with PI3K and Kras
 Pten peptide  >602 publications with PI3K and Pten
 Akt1 peptide  >212 publications with PI3K and Akt1
 Nras peptide  >204 publications with PI3K and Nras
 Pik3r1 peptide  >44 publications with PI3K and Pik3r1
 Hras1 peptide  >1 publications with PI3K and Hras1
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >391 publications with PI3K and Adenocarcinoma
 Colorectal Neoplasms Antibodies  >385 publications with PI3K and Colorectal Neoplasms
 Breast Neoplasms Antibodies  >334 publications with PI3K and Breast Neoplasms
 Lung Neoplasms Antibodies  >206 publications with PI3K and Lung Neoplasms
 Carcinoma, Squamous Cell Antibodies  >196 publications with PI3K and Carcinoma, Squamous Cell
 Neoplasm Metastasis Antibodies  >177 publications with PI3K and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >170 publications with PI3K and Neoplasms, Experimental
 Sarcoma Antibodies  >79 publications with PI3K and Sarcoma
 Liver Neoplasms Antibodies  >63 publications with PI3K and Liver Neoplasms
 Neoplasm Invasiveness Antibodies  >61 publications with PI3K and Neoplasm Invasiveness
Organs/Tissues associated with PI3K peptide
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >292 publications with PI3K and Lung
 Lymph Node Antibodies  >87 publications with PI3K and Lymph Node
 Liver Antibodies  >87 publications with PI3K and Liver
 Brain Antibodies  >74 publications with PI3K and Brain
 Stomach Antibodies  >56 publications with PI3K and Stomach
 Skin Antibodies  >49 publications with PI3K and Skin
 Bladder Antibodies  >41 publications with PI3K and Bladder
 Ovary Antibodies  >26 publications with PI3K and Ovary
 Pancreas Antibodies  >23 publications with PI3K and Pancreas
 Muscle Antibodies  >22 publications with PI3K and Muscle
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