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PIWIL1 peptide :: PIWI / HIWI Peptide

Scan QR to view Datasheet Catalog #    MBS425059 PIWIL1 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PIWI / HIWI (PIWIL1), Peptide

★Popular Item★
 Also Known As   

PIWI / HIWI Immunizing Peptide

 Product Synonym Names    PIWIL1; HIWI; PIWI; piwi-like 1 (Drosophila); piwi (Drosophila)-like 1; homolog of Drosophila piwi; MIWI; piwi homolog; piwi-like 1; PIWI / HIWI
 Product Gene Name   

PIWIL1 peptide

[Similar Products]
 Product Synonym Gene Name    PIWI; HIWI [Similar Products]
 Antibody/Peptide Pairs    PIWI / HIWI peptide (MBS425059) is used for blocking the activity of PIWI/HIWI antibody (MBS420816)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-SNRKDKYD AIKKY
 OMIM    605571
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 Host    Goat
 Species Reactivity    Human, Mouse, Rat, Dog, Pig
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of PIWIL1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for PIWIL1. It may not necessarily be applicable to this product.
 NCBI GI #    66346725
 NCBI GeneID    9271
 NCBI Accession #    NP_004755.2 [Other Products]
 NCBI Related Accession #    NP_001177900.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004764.4 [Other Products]
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 UniProt Secondary Accession #    O95404; Q8NA60; Q8TBY5; Q96JD5; A4F266 [Other Products]
 UniProt Related Accession #    Q96J94 [Other Products]
 Molecular Weight    89,484 Da
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 NCBI Official Full Name    piwi-like protein 1 isoform 1
 NCBI Official Synonym Full Names    piwi like RNA-mediated gene silencing 1
 NCBI Official Symbol    PIWIL1 [Similar Products]
 NCBI Official Synonym Symbols   
HIWI; MIWI; PIWI; CT80.1
[Similar Products]
 NCBI Protein Information    piwi-like protein 1
 UniProt Protein Name    Piwi-like protein 1
 Protein Family    Piwi-like protein
 UniProt Gene Name    PIWIL1 [Similar Products]
 UniProt Synonym Gene Names    HIWI [Similar Products]
 UniProt Entry Name    PIWL1_HUMAN
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 NCBI Summary for PIWIL1    This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
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 UniProt Comments for PIWIL1    PIWIL1: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability. Isoform 3 may be a negative developmental regulator. Interacts (via Piwi domain) with DICER1, suggesting that it forms ribonucleoprotein RISC complexes. This interaction is regulated by HSP90AB1 activity. Interacts with MAEL, KIF17, PABPC1, PRMT5 and WDR77. Interacts (when methylated on arginine residues) with TDRD1, TDRKH/TDRD2, RNF17/TDRD4, TDRD6, TDRD7 and TDRD9. Isoform 3 is down-regulated in CD34(+) hematopoietic cells during differentiation. Detected in most fetal and adult tissues. Expressed in testes, specifically in germline cells; detected in spermatocytes and spermatids during spermatogenesis. Increased expression in testicular tumors originating from embryonic germ cells with retention of germ cells phenotype. No expression in testicular tumors of somatic origin, such as Sertoli cell and Leydig cell tumors. Overexpressed in gastric cancer cells. Isoform 3 is ubiquitously expressed, and specifically in CD34+ hematopoietic progenitor cells but not in more differentiated cells. Belongs to the argonaute family. Piwi subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 12q24.33

Cellular Component: cytoplasm; mRNA cap complex; nucleus; polysome

Molecular Function: mRNA binding; protein binding; protein kinase binding; single-stranded RNA binding

Biological Process: meiotic cell cycle; multicellular organismal development; regulation of translation; RNA-mediated gene silencing; spermatid development
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 Research Articles on PIWIL1    1. results suggested that Piwil1 caused the loss of PTEN expression through DNMT1-mediated PTEN hypermethylation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PIWIL1 peptidePathways associated with PIWIL1 peptide
 Reference Product  PubMed Publications
 TDRD1 peptide  >11 publications with PIWIL1 and TDRD1
 TDRD6 peptide  >3 publications with PIWIL1 and TDRD6
 DICER1 peptide  >3 publications with PIWIL1 and DICER1
 CREM peptide  >2 publications with PIWIL1 and CREM
 KIF17 peptide  >2 publications with PIWIL1 and KIF17
 TDRD7 peptide  >2 publications with PIWIL1 and TDRD7
 MOV10L1 peptide  >2 publications with PIWIL1 and MOV10L1
 TDRKH peptide  >2 publications with PIWIL1 and TDRKH
 SND1 peptide  >1 publications with PIWIL1 and SND1
 Products by Pathway  Pathway Diagram
 Dorso-ventral Axis Formation Pathway antibodies  Dorso-ventral Axis Formation Pathway Diagram
 Dorso-ventral Axis Formation Pathway antibodies  Dorso-ventral Axis Formation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Gene Silencing By RNA Pathway antibodies  Gene Silencing By RNA Pathway Diagram
 PIWI-interacting RNA (piRNA) Biogenesis Pathway antibodies  PIWI-interacting RNA (piRNA) Biogenesis Pathway Diagram
Diseases associated with PIWIL1 peptideOrgans/Tissues associated with PIWIL1 peptide
 Disease Name  Pubmed Publications
 Infertility, Male Antibodies  >10 publications with PIWIL1 and Infertility, Male
 Neoplasm Metastasis Antibodies  >10 publications with PIWIL1 and Neoplasm Metastasis
 Liver Neoplasms Antibodies  >5 publications with PIWIL1 and Liver Neoplasms
 Uterine Cervical Neoplasms Antibodies  >3 publications with PIWIL1 and Uterine Cervical Neoplasms
 Ovarian Neoplasms Antibodies  >3 publications with PIWIL1 and Ovarian Neoplasms
 Kidney Diseases Antibodies  >2 publications with PIWIL1 and Kidney Diseases
 Disease Models, Animal Antibodies  >2 publications with PIWIL1 and Disease Models, Animal
 Growth Disorders Antibodies  >1 publications with PIWIL1 and Growth Disorders
 Fetal Death Antibodies  >1 publications with PIWIL1 and Fetal Death
 Necrosis Antibodies  >1 publications with PIWIL1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >59 publications with PIWIL1 and Testis
 Brain Antibodies  >6 publications with PIWIL1 and Brain
 Uterus Antibodies  >1 publications with PIWIL1 and Uterus
 Muscle Antibodies  >1 publications with PIWIL1 and Muscle
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