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PLDN peptide :: Pallidin Peptide

Scan QR to view Datasheet Catalog #    MBS425308 PLDN peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Pallidin (PLDN), Peptide

 Also Known As   

Pallidin Immunizing Peptide

 Product Synonym Names    pallidin homolog (mouse); pallidin; PLDN; PA; PALLID; pallid (mouse) homolog, pallidin; syntaxin 13 binding protein 1; syntaxin 13-interacting protein pallid; Pallidin; Pallidin
 Product Gene Name   

PLDN peptide

[Similar Products]
 Antibody/Peptide Pairs    Pallidin peptide (MBS425308) is used for blocking the activity of Pallidin antibody (MBS421440)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-EREKQLTA RPAKRM
 OMIM    604310
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 Species Reactivity    Human, Mouse, Rat, Pig, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of PLDN peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for PLDN. It may not necessarily be applicable to this product.
 NCBI GI #    6912574
 NCBI GeneID    26258
 NCBI Accession #    NP_036520.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012388.3 [Other Products]
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 UniProt Related Accession #    Q9UL45 [Other Products]
 Molecular Weight    – Da
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 NCBI Official Full Name    biogenesis of lysosome-related organelles complex 1 subunit 6 isoform 2
 NCBI Official Synonym Full Names    biogenesis of lysosomal organelles complex 1 subunit 6
 NCBI Official Symbol    BLOC1S6 [Similar Products]
 NCBI Official Synonym Symbols   
PA; HPS9; PLDN; BLOS6; PALLID
[Similar Products]
 NCBI Protein Information    biogenesis of lysosome-related organelles complex 1 subunit 6
 UniProt Protein Name    Biogenesis of lysosome-related organelles complex 1 subunit 6
 UniProt Synonym Protein Names   
Pallid protein homolog; Pallidin; Syntaxin 13-interacting protein
 UniProt Gene Name    BLOC1S6 [Similar Products]
 UniProt Synonym Gene Names    PA; PLDN; BLOC-1 subunit 6 [Similar Products]
 UniProt Entry Name    BL1S6_HUMAN
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 NCBI Summary for PLDN    The protein encoded by this gene may play a role in intracellular vesicle trafficking. It interacts with Syntaxin 13 which mediates intracellular membrane fusion. Mutations in this gene cause symptoms associated with Hermansky-Pudlak syndrome-9. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome. [provided by RefSeq, Aug 2015]
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 UniProt Comments for PLDN    PLDN: Involved in the development of lysosome-related organelles, such as melanosomes and platelet-dense granules. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. Defects in PLDN are the cause of Hermansky-Pudlak syndrome type 9 (HPS9). A form of Hermansky-Pudlak syndrome, a genetically heterogeneous autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 15q21.1

Cellular Component: cytoplasm; cytosol; endosome; extrinsic to membrane; nucleoplasm; SNARE complex; transport vesicle

Molecular Function: actin filament binding; identical protein binding; protein binding; protein homodimerization activity; syntaxin binding

Biological Process: anterograde axon cargo transport; anterograde synaptic vesicle transport; blood coagulation; melanocyte differentiation; melanosome organization and biogenesis; melanosome transport; neurite development; positive regulation of natural killer cell activation; positive regulation of pigment cell differentiation; secretion of lysosomal enzymes; synaptic vesicle docking during exocytosis

Disease: Hermansky-pudlak Syndrome 9
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 Research Articles on PLDN    1. Mecp2 regulates the expression of components belonging to the dysbindin interactome
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PLDN peptideDiseases associated with PLDN peptide
 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram
 Disease Name  Pubmed Publications
 Hemorrhage Antibodies  >1 publications with PLDN and Hemorrhage
 Fibrosis Antibodies  >1 publications with PLDN and Fibrosis
Organs/Tissues associated with PLDN peptide
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with PLDN and Blood
 Lung Antibodies  >1 publications with PLDN and Lung
 Eye Antibodies  >1 publications with PLDN and Eye
 Skin Antibodies  >1 publications with PLDN and Skin
 Brain Antibodies  >1 publications with PLDN and Brain
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