NP_002658.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
6,109 Da
NCBI Official Full Name
cardiac phospholamban
NCBI Official Synonym Full Names
phospholamban
NCBI Protein Information
cardiac phospholamban
UniProt Protein Name
Cardiac phospholamban
UniProt Synonym Gene Names
UniProt Entry Name
PPLA_HUMAN
NCBI Summary for PLN
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
UniProt Comments for PLN
PLB: a heart protein postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum. A major substrate for the cAMP-dependent protein kinase. An inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. A key regulator of cardiac diastolic function. Mutations are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.
Protein type: Membrane protein, integral; Inhibitor
Chromosomal Location of Human Ortholog: 6q22.1
Cellular Component: endoplasmic reticulum; membrane; mitochondrial membrane; mitochondrion; perinuclear region of cytoplasm; sarcoplasmic reticulum membrane; vesicle
Molecular Function: ATPase binding; ATPase inhibitor activity; calcium channel regulator activity; enzyme inhibitor activity; identical protein binding; protein binding
Biological Process: blood circulation; calcium ion transport; cardiac muscle development; cytosolic calcium ion homeostasis; negative regulation of ATPase activity; negative regulation of calcium ion transport; negative regulation of catalytic activity; negative regulation of heart rate; Notch signaling pathway; protein homooligomerization; regulation of calcium ion transport; regulation of heart contraction; regulation of the force of heart contraction; response to insulin stimulus; response to testosterone stimulus; response to zinc ion
Disease: Cardiomyopathy, Dilated, 1p; Cardiomyopathy, Familial Hypertrophic, 18
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Products associated with PLN blocking peptide
Pathways associated with PLN blocking peptide
Diseases associated with PLN blocking peptide
Organs/Tissues associated with PLN blocking peptide
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