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TTR peptide :: Prealbumin / Transthyretin Peptide

Scan QR to view Datasheet Catalog #    MBS425685 TTR peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Prealbumin / Transthyretin (TTR), Peptide

 Also Known As   

Prealbumin / Transthyretin Immunizing Peptide

 Product Synonym Names    TTR; transthyretin (prealbumin, amyloidosis type I); HGNC: 12405; HsT2651; PALB; TBPA; prealbumin; transthyretin; Prealbumin; Transthyretin; Prealbumin / Transthyretin
 Product Gene Name   

TTR peptide

[Similar Products]
 Antibody/Peptide Pairs    Prealbumin / Transthyretin peptide (MBS425685) is used for blocking the activity of Prealbumin/Transthyretin antibody (MBS420933)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-YKVEIDTK SYWK
 OMIM    105210
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 Species Reactivity    Human, Mouse, Rat, Dog
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of TTR peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for TTR. It may not necessarily be applicable to this product.
 NCBI GI #    4507725
 NCBI GeneID    7276
 NCBI Accession #    NP_000362.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000371.3 [Other Products]
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 UniProt Secondary Accession #    Q549C7; Q6IB96; Q9UBZ6; Q9UCM9 [Other Products]
 UniProt Related Accession #    P02766 [Other Products]
 Molecular Weight    15,887 Da
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 NCBI Official Full Name    transthyretin
 NCBI Official Synonym Full Names    transthyretin
 NCBI Official Symbol    TTR [Similar Products]
 NCBI Official Synonym Symbols   
CTS; CTS1; PALB; TBPA; HEL111; HsT2651
[Similar Products]
 NCBI Protein Information    transthyretin
 UniProt Protein Name    Transthyretin
 UniProt Synonym Protein Names   
ATTR; Prealbumin; TBPA
 Protein Family    Transthyretin
 UniProt Gene Name    TTR [Similar Products]
 UniProt Synonym Gene Names    PALB [Similar Products]
 UniProt Entry Name    TTHY_HUMAN
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 NCBI Summary for TTR    This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]
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 UniProt Comments for TTR    TTR: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR). A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE). It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities. Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1). It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis. Belongs to the transthyretin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: cytoplasm; extracellular region; extracellular space; protein complex

Molecular Function: hormone activity; hormone binding; identical protein binding; protein binding; protein heterodimerization activity

Biological Process: cellular protein metabolic process; extracellular matrix organization and biogenesis; retinoid metabolic process; retinol metabolic process; transport

Disease: Amyloidosis, Hereditary, Transthyretin-related; Carpal Tunnel Syndrome; Hyperthyroxinemia, Dystransthyretinemic
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 Research Articles on TTR    1. study reports a novel TTR variant(TTR Asp38Tyr mutation) in 2 Brazilian sisters who developed a late onset neuropathy; new mutation calls attention to the diversity found in TTR familial amyloid polyneuropathy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TTR peptidePathways associated with TTR peptide
 Reference Product  PubMed Publications
 RBP4 peptide  >42 publications with TTR and RBP4
 APP peptide  >19 publications with TTR and APP
 APOA1 peptide  >11 publications with TTR and APOA1
 HNF4A peptide  >5 publications with TTR and HNF4A
 IAPP peptide  >5 publications with TTR and IAPP
 APOA4 peptide  >2 publications with TTR and APOA4
 LYZ peptide  >1 publications with TTR and LYZ
 GSN peptide  >1 publications with TTR and GSN
 CST3 peptide  >1 publications with TTR and CST3
 Products by Pathway  Pathway Diagram
 Amyloid Fiber Formation Pathway antibodies  Amyloid Fiber Formation Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
Diseases associated with TTR peptideOrgans/Tissues associated with TTR peptide
 Disease Name  Pubmed Publications
 Amyloidosis Antibodies  >964 publications with TTR and Amyloidosis
 Nervous System Diseases Antibodies  >744 publications with TTR and Nervous System Diseases
 Amyloidosis, Familial Antibodies  >664 publications with TTR and Amyloidosis, Familial
 Amyloid Neuropathies, Familial Antibodies  >462 publications with TTR and Amyloid Neuropathies, Familial
 Cardiovascular Diseases Antibodies  >309 publications with TTR and Cardiovascular Diseases
 Heart Diseases Antibodies  >264 publications with TTR and Heart Diseases
 Liver Diseases Antibodies  >159 publications with TTR and Liver Diseases
 Liver Neoplasms Antibodies  >87 publications with TTR and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >83 publications with TTR and Carcinoma, Hepatocellular
 Inflammation Antibodies  >82 publications with TTR and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >549 publications with TTR and Liver
 Heart Antibodies  >322 publications with TTR and Heart
 Brain Antibodies  >283 publications with TTR and Brain
 Muscle Antibodies  >137 publications with TTR and Muscle
 Kidney Antibodies  >128 publications with TTR and Kidney
 Eye Antibodies  >103 publications with TTR and Eye
 Lung Antibodies  >70 publications with TTR and Lung
 Skin Antibodies  >55 publications with TTR and Skin
 Embryonic Tissue Antibodies  >33 publications with TTR and Embryonic Tissue
 Pancreas Antibodies  >31 publications with TTR and Pancreas
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