NP_057361.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,659 Da
NCBI Official Full Name
ras-related protein Rab-23
NCBI Official Synonym Full Names
RAB23, member RAS oncogene family
NCBI Official Synonym Symbols
NCBI Protein Information
ras-related protein Rab-23
UniProt Protein Name
Ras-related protein Rab-23
UniProt Entry Name
RAB23_HUMAN
NCBI Summary for RAB23
This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for RAB23
RAB23: Defects in RAB23 are the cause of acrocephalopolysyndactyly type 2 (ACPS2). A syndrome characterized by craniosynostosis, polysyndactyly, obesity, and cardiac defects. Belongs to the small GTPase superfamily. Rab family.
Protein type: G protein, monomeric; G protein, monomeric, Rab; G protein
Chromosomal Location of Human Ortholog: 6p11
Cellular Component: autophagic vacuole; cytoplasm; endosome membrane; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane
Molecular Function: GTP binding; GTPase activity; protein binding
Biological Process: autophagic vacuole formation; cellular defense response; cilium biogenesis; intracellular protein transport; metabolic process; negative regulation of transcription factor import into nucleus; nucleocytoplasmic transport; small GTPase mediated signal transduction
Disease: Carpenter Syndrome 1
Research Articles on RAB23
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Products associated with RAB23 blocking peptide
Pathways associated with RAB23 blocking peptide
Diseases associated with RAB23 blocking peptide
Organs/Tissues associated with RAB23 blocking peptide
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