NP_003601.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,968 Da
NCBI Official Full Name
mRNA export factor
NCBI Official Synonym Full Names
ribonucleic acid export 1
NCBI Official Synonym Symbols
MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1 [Similar Products]
NCBI Protein Information
mRNA export factor
UniProt Protein Name
mRNA export factor
UniProt Synonym Protein Names
Rae1 protein homolog; mRNA-associated protein mrnp 41
UniProt Synonym Gene Names
UniProt Entry Name
RAE1L_HUMAN
NCBI Summary for RAE1
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for RAE1
RAE1: Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Belongs to the WD repeat rae1 family.
Protein type: Motility/polarity/chemotaxis; RNA-binding
Chromosomal Location of Human Ortholog: 20q13.31
Cellular Component: cytoplasm; nuclear envelope; nuclear pore; nucleolus; nucleus
Molecular Function: microtubule binding; RNA binding; ubiquitin binding
Biological Process: mitotic nuclear envelope disassembly; mRNA export from nucleus; protein import into nucleus; protein sumoylation; RNA-mediated gene silencing; tRNA export from nucleus; viral reproduction; viral transcription
Research Articles on RAE1
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Products associated with RAE1 blocking peptide
Pathways associated with RAE1 blocking peptide
Diseases associated with RAE1 blocking peptide
Organs/Tissues associated with RAE1 blocking peptide
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