NP_631904
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,978 Da
NCBI Official Full Name
NKG2D ligand 4 isoform 1
NCBI Official Synonym Full Names
retinoic acid early transcript 1E
NCBI Official Synonym Symbols
RL-4; LETAL; ULBP4; N2DL-4; NKG2DL4; RAET1E2; bA350J20.7 [Similar Products]
NCBI Protein Information
NKG2D ligand 4
UniProt Protein Name
NKG2D ligand 4
UniProt Synonym Protein Names
Lymphocyte effector toxicity activation ligand; RAE-1-like transcript 4; RL-4; Retinoic acid early transcript 1E
UniProt Synonym Gene Names
UniProt Entry Name
N2DL4_HUMAN
NCBI Summary for RAET1E
This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
UniProt Comments for RAET1E
RAET1E: Ligand for the NKG2D receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes. Belongs to the MHC class I family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 6q25.1
Cellular Component: extracellular region; integral to membrane; plasma membrane
Molecular Function: antigen binding; natural killer cell lectin-like receptor binding
Biological Process: antigen processing and presentation; natural killer cell mediated cytotoxicity; regulation of immune response; T cell mediated cytotoxicity
Product References and Citations for RAET1E blocking peptide
Radosavlijevic M, Cuillerier B, Wilson MJ, et al. A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. Genomics 2002; 79:114-23.
Research Articles on RAET1E
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Pathways associated with RAET1E blocking peptide
Diseases associated with RAET1E blocking peptide
Organs/Tissues associated with RAET1E blocking peptide
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