NP_002933.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
153,120 Da
NCBI Official Full Name
roundabout homolog 2 isoform ROBO2b
NCBI Official Synonym Full Names
roundabout guidance receptor 2
NCBI Official Synonym Symbols
NCBI Protein Information
roundabout homolog 2
UniProt Protein Name
Roundabout homolog 2
UniProt Synonym Gene Names
UniProt Entry Name
ROBO2_HUMAN
NCBI Summary for ROBO2
The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
UniProt Comments for ROBO2
ROBO2: Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Defects in ROBO2 are the cause of vesicoureteral reflux type 2 (VUR2). VUR is a complex, genetically heterogeneous developmental disorder characterized by the retrograde flow of urine from the bladder into the ureter and is associated with reflux nephropathy, the cause of 15% of end-stage renal disease in children and young adults. A chromosomal aberration involving ROBO2 is a cause of multiple congenital abnormalities, including severe bilateral VUR with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with PCDH11Y. This translocation disrupts ROBO2 and produces dominant-negative ROBO2 proteins that abrogate SLIT- ROBO signaling in vitro. Belongs to the immunoglobulin superfamily. ROBO family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p12.3
Cellular Component: axolemma; cell surface
Molecular Function: axon guidance receptor activity; identical protein binding; protein binding
Biological Process: axon guidance; axon midline choice point recognition; brain development; cellular response to hormone stimulus; homophilic cell adhesion; metanephros development; negative regulation of negative chemotaxis; negative regulation of synaptogenesis; olfactory bulb interneuron development; positive regulation of axonogenesis; retinal ganglion cell axon guidance; ureteric bud development
Disease: Vesicoureteral Reflux 2
Research Articles on ROBO2
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Products associated with ROBO2 blocking peptide
Pathways associated with ROBO2 blocking peptide
Diseases associated with ROBO2 blocking peptide
Organs/Tissues associated with ROBO2 blocking peptide
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