CAG47070.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
RAB8A
NCBI Official Synonym Full Names
RAB8A, member RAS oncogene family
NCBI Official Synonym Symbols
NCBI Protein Information
ras-related protein Rab-8A; oncogene c-mel; ras-associated protein RAB8; mel transforming oncogene (RAB8 homolog); mel transforming oncogene (derived from cell line NK14); mel transforming oncogene (derived from cell line NK14)- RAB8 homolog
UniProt Protein Name
Ras-related protein Rab-8A
UniProt Synonym Protein Names
Oncogene c-mel
UniProt Synonym Gene Names
UniProt Entry Name
RAB8A_HUMAN
NCBI Summary for RAB8A
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]
UniProt Comments for RAB8A
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis. Ref.16 Ref.19 Ref.22
Enzyme regulation: Activated in response to insulin
By similarity.
Subunit structure: Interacts with MAP4K2 and SYTL4. Interacts with SGSM1 and SGSM3
By similarity. Interacts with RABIF, RIMS2, RPH3A and RPH3A
By similarity. Interacts with MICALL2; competes with RAB13 and is involved in E-cadherin endocytic recycling
By similarity. Interacts with MICAL1 and MICALL1
By similarity. Interacts with OPTN. Interacts with RAB3IP. Interacts with MYO5B. Interacts with PIFO. Interacts with BIRC6/bruce. Interacts with OCRL. Ref.9 Ref.10 Ref.12 Ref.15 Ref.19 Ref.23
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side
Potential. Golgi apparatus. Cytoplasm › perinuclear region. Recycling endosome membrane
By similarity. Cell projection › cilium. Cytoplasmic vesicle › phagosome. Cytoplasmic vesicle › phagosome membrane; Lipid-anchor; Cytoplasmic side
By similarity. Note: Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane. In the GDP-bound form, present in the perinuclear region. Shows a polarized distribution to distal regions of cell protrusions in the GTP-bound form. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Recruited to phagosomes containing S.aureus or M.tuberculosis. Ref.9 Ref.10 Ref.16 Ref.21 Ref.22
Sequence similarities: Belongs to the small GTPase superfamily. Rab family.
Research Articles on RAB8A
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Products associated with RAB8A peptide
Pathways associated with RAB8A peptide
Diseases associated with RAB8A peptide
Organs/Tissues associated with RAB8A peptide
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