CAG30441.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
RAC2
NCBI Official Synonym Full Names
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
NCBI Protein Information
ras-related C3 botulinum toxin substrate 2; small G protein; Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2)
UniProt Protein Name
Ras-related C3 botulinum toxin substrate 2
UniProt Synonym Protein Names
GX; Small G protein; p21-Rac2
UniProt Entry Name
RAC2_HUMAN
NCBI Summary for RAC2
This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]
UniProt Comments for RAC2
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. Ref.8
Enzyme regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.
Subunit structure: Interacts with DOCK2, which may activate it. Interacts with S100A8 and calprotectin (S100A8/9). Ref.12 Ref.13
Subcellular location: Cytoplasm. Note: Membrane-associated when activated.
Tissue specificity: Hematopoietic specific.
Involvement in disease: Neutrophil immunodeficiency syndrome (NEUID) [MIM:608203]: An immunodeficiency syndrome due to defective neutrophils. Affected individuals present with leukocytosis, neutrophilia, severe recurrent bacterial infections and poor wound healing.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.17
Sequence similarities: Belongs to the small GTPase superfamily. Rho family.
Research Articles on RAC2
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Products associated with RAC2 peptide
Pathways associated with RAC2 peptide
Diseases associated with RAC2 peptide
Organs/Tissues associated with RAC2 peptide
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