NP_002897.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
71,049 Da
NCBI Official Full Name
radixin isoform 2
NCBI Official Synonym Full Names
radixin
NCBI Official Synonym Symbols
NCBI Protein Information
radixin
UniProt Protein Name
Radixin
UniProt Entry Name
RADI_HUMAN
NCBI Summary for RDX
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
UniProt Comments for RDX
Radixin: a cytoskeletal protein of the ERM family which includes ezrin and moiesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. May play a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11q23
Cellular Component: apical plasma membrane; cleavage furrow; cortical actin cytoskeleton; extracellular space; extrinsic to membrane; filopodium; focal adhesion; lamellipodium; microvillus; myelin sheath; plasma membrane; ruffle; stereocilium
Molecular Function: actin binding; ATPase binding; protein binding; protein domain specific binding; protein homodimerization activity; protein kinase A binding
Biological Process: actin filament capping; apical protein localization; establishment of protein localization; microvillus biogenesis; negative regulation of cell size; negative regulation of homotypic cell-cell adhesion; positive regulation of cell migration; regulation of actin filament bundle formation; regulation of cell shape; regulation of cell size; regulation of GTPase activity; regulation of Rap protein signal transduction
Disease: Deafness, Autosomal Recessive 24
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with RDX blocking peptide
Pathways associated with RDX blocking peptide
Diseases associated with RDX blocking peptide
Organs/Tissues associated with RDX blocking peptide
|