NP_001026879.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,949 Da
NCBI Official Full Name
renalase isoform 1
NCBI Official Synonym Full Names
renalase, FAD-dependent amine oxidase
NCBI Protein Information
renalase
UniProt Protein Name
Renalase
UniProt Synonym Protein Names
Monoamine oxidase-C; MAO-C
UniProt Synonym Gene Names
UniProt Entry Name
RNLS_HUMAN
NCBI Summary for C10orf59
Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]
UniProt Comments for C10orf59
RENALASE: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity. Belongs to the renalase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; EC 1.6.3.5; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10q23.31
Cellular Component: extracellular space
Molecular Function: oxidoreductase activity
Research Articles on C10orf59
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Diseases associated with C10orf59 blocking peptide
Organs/Tissues associated with C10orf59 blocking peptide
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