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SET peptide :: SET / I2 alpha PP2A Peptide

Scan QR to view Datasheet Catalog #    MBS425265 SET peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SET / I2 alpha PP2A, Peptide

 Also Known As   

SET / I2 alpha PP2A Immunizing Peptide

 Product Synonym Names    SET; SET nuclear oncogene; 2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII; TAF-I; TAF-IBETA; LA-DR-associated protein II; OTTHUMP00000022286; SET translocation (myeloid leukemia-associated); Template-Activating Factor-I, chromatin remodelling factor; inhibitor of g; I2 alpha PP2A; SET / I2 alpha PP2A
 Product Gene Name   

SET peptide

[Similar Products]
 Antibody/Peptide Pairs    SET / I2 alpha PP2A peptide (MBS425265) is used for blocking the activity of SET/I2 alpha PP2A antibody (MBS420767)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600960
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 Species Reactivity    Human, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of SET peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for SET. It may not necessarily be applicable to this product.
 NCBI GI #    170763498
 NCBI GeneID    6418
 NCBI Accession #    NP_003002.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003011.3 [Other Products]
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 UniProt Secondary Accession #    Q15541; Q5VXV1; Q5VXV2; Q6FHZ5; A5A5H4; A6NGV1; B4DUE2 [Other Products]
 UniProt Related Accession #    Q01105 [Other Products]
 Molecular Weight    31,272 Da
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 NCBI Official Full Name    protein SET isoform 2
 NCBI Official Synonym Full Names    SET nuclear proto-oncogene
 NCBI Official Symbol    SET [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    protein SET
 UniProt Protein Name    Protein SET
 UniProt Synonym Protein Names   
HLA-DR-associated protein II; Inhibitor of granzyme A-activated DNase; IGAAD; PHAPII; Phosphatase 2A inhibitor I2PP2A; I-2PP2A; Template-activating factor I; TAF-I
 Protein Family    Protein
 UniProt Gene Name    SET [Similar Products]
 UniProt Synonym Gene Names    IGAAD; I-2PP2A; TAF-I [Similar Products]
 UniProt Entry Name    SET_HUMAN
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 NCBI Summary for SET    The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for SET    SET: a potent inhibitor of protein phosphatase 2A involved in apoptosis, transcription, nucleosome assembly and histone binding. The translocation t(6;9)(q21;q34.1) NUP214/CAN is found in some cases of acute undifferentiated leukemia (AUL). Two alternatively spliced isoforms have been described. Isoform 1 and isoform 2 interact directly with each other and with ANP32A within the tripartite INHAT (inhibitor of acetyltransferases) complex. Both isoforms inhibit the acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition.

Protein type: DNA-binding; Oncoprotein; DNA replication; Nuclear receptor co-regulator; Apoptosis; Inhibitor

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein complex

Molecular Function: DNA binding; histone binding; protein binding; protein phosphatase inhibitor activity; protein phosphatase type 2A regulator activity

Biological Process: DNA replication; negative regulation of catalytic activity; negative regulation of histone acetylation; negative regulation of neuron apoptosis; negative regulation of transcription, DNA-dependent; nucleocytoplasmic transport; nucleosome assembly; nucleosome disassembly; regulation of mRNA stability; regulation of protein phosphatase type 2A activity; viral reproduction
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 Research Articles on SET    1. Data show that the biogical effect of inhibitor-2 of protein phosphatase-2A (SET) on proliferation and invasion was mediated by the inhibition of the protein phosphatase 2A (PP2A).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SET peptidePathways associated with SET peptide
 Reference Product  PubMed Publications
 UBC peptide  >486 publications with SET and UBC
 NUP214 peptide  >34 publications with SET and NUP214
 NME1 peptide  >22 publications with SET and NME1
 APEX1 peptide  >19 publications with SET and APEX1
 ANP32A peptide  >19 publications with SET and ANP32A
 HMGB2 peptide  >16 publications with SET and HMGB2
 ELAVL1 peptide  >14 publications with SET and ELAVL1
 GZMA peptide  >13 publications with SET and GZMA
 PPP2CA peptide  >8 publications with SET and PPP2CA
 XPO1 peptide  >8 publications with SET and XPO1
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Condensation Of Prophase Chromosomes Pathway antibodies  Condensation Of Prophase Chromosomes Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 HuR (ELAVL1) Binds And Stabilizes MRNA Pathway antibodies  HuR (ELAVL1) Binds And Stabilizes MRNA Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Prophase Pathway antibodies  Mitotic Prophase Pathway Diagram
 Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway antibodies  Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway Diagram
Diseases associated with SET peptideOrgans/Tissues associated with SET peptide
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >24520 publications with SET and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >15190 publications with SET and Cardiovascular Diseases
 Immune System Diseases Antibodies  >11239 publications with SET and Immune System Diseases
 Heart Diseases Antibodies  >7783 publications with SET and Heart Diseases
 Inflammation Antibodies  >5275 publications with SET and Inflammation
 Breast Neoplasms Antibodies  >5022 publications with SET and Breast Neoplasms
 Congenital Abnormalities Antibodies  >4530 publications with SET and Congenital Abnormalities
 Disease Models, Animal Antibodies  >4476 publications with SET and Disease Models, Animal
 Liver Diseases Antibodies  >3843 publications with SET and Liver Diseases
 Hypertension Antibodies  >3756 publications with SET and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >39385 publications with SET and Blood
 Brain Antibodies  >26417 publications with SET and Brain
 Heart Antibodies  >13529 publications with SET and Heart
 Muscle Antibodies  >11753 publications with SET and Muscle
 Bone Antibodies  >11630 publications with SET and Bone
 Vascular Antibodies  >9420 publications with SET and Vascular
 Lung Antibodies  >8678 publications with SET and Lung
 Liver Antibodies  >8305 publications with SET and Liver
 Skin Antibodies  >7299 publications with SET and Skin
 Eye Antibodies  >6933 publications with SET and Eye
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