NP_001037.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
129,679 Da
NCBI Official Full Name
solute carrier family 12 member 2 isoform 1
NCBI Official Synonym Full Names
solute carrier family 12 member 2
NCBI Protein Information
solute carrier family 12 member 2
UniProt Protein Name
Solute carrier family 12 member 2
UniProt Synonym Protein Names
Basolateral Na-K-Cl symporter; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
UniProt Synonym Gene Names
UniProt Entry Name
S12A2_HUMAN
NCBI Summary for SLC12A2
The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for SLC12A2
NKCC1: a multi-pass membrane cation transporter protein. Aids transcellular movement of chloride across both secretory and absorptive epithelia. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Expressed in many tissues. Bumetanide is a potent NKCC1 antagonist. Two alternatively spliced isoforms have been described.
Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5q23.3
Cellular Component: apical plasma membrane; integral to plasma membrane; membrane; plasma membrane
Molecular Function: ammonium transmembrane transporter activity; protein binding; sodium:potassium:chloride symporter activity
Biological Process: ammonium transport; ion transport; potassium ion transport; sodium ion transport; transepithelial chloride transport; transport
Research Articles on SLC12A2
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Products associated with SLC12A2 blocking peptide
Pathways associated with SLC12A2 blocking peptide
Diseases associated with SLC12A2 blocking peptide
Organs/Tissues associated with SLC12A2 blocking peptide
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