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SPEN peptide :: SPEN / SHARP Peptide

Scan QR to view Datasheet Catalog #    MBS426069 SPEN peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SPEN / SHARP, Peptide

 Also Known As   

SPEN / SHARP Immunizing Peptide

 Product Synonym Names    SPEN; spen homolog, transcriptional regulator (Drosophila); KIAA0929; MINT; RP1-134O19.1; SHARP; Msx2 interacting nuclear target (MINT) homolog; OTTHUMP00000044600; SMART/HDAC1 associated repressor protein; nuclear receptor transcription cofactor spen ho; SPEN / SHARP
 Product Gene Name   

SPEN peptide

[Similar Products]
 Product Synonym Gene Name    SHARP [Similar Products]
 Antibody/Peptide Pairs    SPEN / SHARP peptide (MBS426069) is used for blocking the activity of SPEN/SHARP antibody (MBS420428)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-DSEGKMDD KKEDHKE
 OMIM    613484
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 Species Reactivity    Human
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of SPEN peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for SPEN. It may not necessarily be applicable to this product.
 NCBI GI #    14790190
 NCBI GeneID    23013
 NCBI Accession #    NP_055816.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_015001.2 [Other Products]
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 UniProt Secondary Accession #    Q9H9A8; Q9NWH5; Q9UQ01; Q9Y556 [Other Products]
 UniProt Related Accession #    Q96T58 [Other Products]
 Molecular Weight    402,248 Da
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 NCBI Official Full Name    msx2-interacting protein
 NCBI Official Synonym Full Names    spen family transcriptional repressor
 NCBI Official Symbol    SPEN [Similar Products]
 NCBI Official Synonym Symbols   
MINT; SHARP; RBM15C; HIAA0929
[Similar Products]
 NCBI Protein Information    msx2-interacting protein
 UniProt Protein Name    Msx2-interacting protein
 UniProt Synonym Protein Names   
SMART/HDAC1-associated repressor protein; SPEN homolog
 Protein Family    Protein split ends
 UniProt Gene Name    SPEN [Similar Products]
 UniProt Synonym Gene Names    KIAA0929; MINT; SHARP [Similar Products]
 UniProt Entry Name    MINT_HUMAN
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 NCBI Summary for SPEN    This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SPEN    SHARP: May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2- mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. Belongs to the RRM Spen family.

Protein type: Nuclear receptor co-regulator; Transcription factor; Spliceosome; RNA-binding

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: nucleoplasm; nucleus; transcriptional repressor complex

Molecular Function: DNA binding; nucleic acid binding; nucleotide binding; protein binding

Biological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; Notch signaling pathway; nuclear mRNA splicing, via spliceosome; positive regulation of neurogenesis; transcription, DNA-dependent; viral reproduction
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 Research Articles on SPEN    1. SPEN is a novel tumor-suppressor gene that may be clinically useful as a predictive biomarker of tamoxifen response in ERalpha-positive breast cancers.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SPEN peptidePathways associated with SPEN peptide
 Reference Product  PubMed Publications
 NOTCH1 peptide  >4 publications with SPEN and NOTCH1
 RBPJ peptide  >4 publications with SPEN and RBPJ
 NCOR2 peptide  >3 publications with SPEN and NCOR2
 HEY1 peptide  >1 publications with SPEN and HEY1
 EP300 peptide  >1 publications with SPEN and EP300
 Products by Pathway  Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
Diseases associated with SPEN peptideOrgans/Tissues associated with SPEN peptide
 Disease Name  Pubmed Publications
 Death Antibodies  >7 publications with SPEN and Death
 Adenocarcinoma Antibodies  >7 publications with SPEN and Adenocarcinoma
 Breast Neoplasms Antibodies  >5 publications with SPEN and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with SPEN and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >3 publications with SPEN and Nervous System Diseases
 Liver Diseases Antibodies  >2 publications with SPEN and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with SPEN and Liver Neoplasms
 Lung Diseases Antibodies  >2 publications with SPEN and Lung Diseases
 Adenoma Antibodies  >2 publications with SPEN and Adenoma
 Carcinoma, Hepatocellular Antibodies  >1 publications with SPEN and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >23 publications with SPEN and Brain
 Blood Antibodies  >15 publications with SPEN and Blood
 Eye Antibodies  >10 publications with SPEN and Eye
 Pancreas Antibodies  >9 publications with SPEN and Pancreas
 Embryonic Tissue Antibodies  >7 publications with SPEN and Embryonic Tissue
 Liver Antibodies  >7 publications with SPEN and Liver
 Muscle Antibodies  >6 publications with SPEN and Muscle
 Heart Antibodies  >5 publications with SPEN and Heart
 Bone Antibodies  >5 publications with SPEN and Bone
 Vascular Antibodies  >4 publications with SPEN and Vascular
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