NP_006653.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
327,838 Da
NCBI Official Full Name
helicase SRCAP
NCBI Official Synonym Full Names
Snf2-related CREBBP activator protein
NCBI Protein Information
helicase SRCAP
UniProt Protein Name
Helicase SRCAP
UniProt Synonym Protein Names
Domino homolog 2; Snf2-related CBP activator
UniProt Synonym Gene Names
UniProt Entry Name
SRCAP_HUMAN
NCBI Summary for SRCAP
This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
UniProt Comments for SRCAP
SRCAP: Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. Defects in SRCAP are the cause of Floating-Harbor syndrome (FLHS). A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; EC 3.6.1.-; Helicase; Acetyltransferase; EC 3.6.4.-; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: Golgi apparatus; nucleus; perinuclear region of cytoplasm; protein complex
Molecular Function: ATP binding; DNA binding; helicase activity; histone acetyltransferase activity; protein binding; transcription coactivator activity
Biological Process: histone acetylation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction
Disease: Floating-harbor Syndrome
Research Articles on SRCAP
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Diseases associated with SRCAP blocking peptide
Disease Name |
Pubmed Publications |
Heart Defects, Congenital Antibodies |
>9 publications with SRCAP and Heart Defects, Congenital |
Congenital, Hereditary, and Neonatal Diseases and Abnormalities Antibodies |
>9 publications with SRCAP and Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
Abnormalities, Multiple Antibodies |
>9 publications with SRCAP and Abnormalities, Multiple |
Liver Diseases Antibodies |
>8 publications with SRCAP and Liver Diseases |
Carcinoma, Hepatocellular Antibodies |
>8 publications with SRCAP and Carcinoma, Hepatocellular |
Liver Neoplasms Antibodies |
>8 publications with SRCAP and Liver Neoplasms |
Neoplasms, Experimental Antibodies |
>4 publications with SRCAP and Neoplasms, Experimental |
Liver Neoplasms, Experimental Antibodies |
>3 publications with SRCAP and Liver Neoplasms, Experimental |
Chromosome Aberrations Antibodies |
>2 publications with SRCAP and Chromosome Aberrations |
Prostatic Diseases Antibodies |
>2 publications with SRCAP and Prostatic Diseases |
Organs/Tissues associated with SRCAP blocking peptide
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