NP_055079.3
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
serine/threonine-protein kinase PLK4 isoform 1
NCBI Official Synonym Full Names
polo like kinase 4
NCBI Protein Information
serine/threonine-protein kinase PLK4
UniProt Protein Name
Serine/threonine-protein kinase PLK4
UniProt Synonym Protein Names
Polo-like kinase 4; PLK-4; Serine/threonine-protein kinase 18; Serine/threonine-protein kinase Sak
UniProt Synonym Gene Names
UniProt Entry Name
PLK4_HUMAN
NCBI Summary for PLK4
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
UniProt Comments for PLK4
PLK4: a kinase of the PLK family. Localizes to centrosomes and the cleavage furrow during cytokinesis. Interacts with the protein kinase Tec.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.21; Nucleolus; Protein kinase, Other; Other group; PLK family
Chromosomal Location of Human Ortholog: 4q28
Cellular Component: centriole; centrosome; cleavage furrow; cytosol; nucleolus; XY body
Molecular Function: ATP binding; identical protein binding; protein binding; protein serine/threonine kinase activity
Biological Process: centriole replication; G2/M transition of mitotic cell cycle; positive regulation of centriole replication; protein amino acid phosphorylation
Disease: Microcephaly And Chorioretinopathy, Autosomal Recessive, 2
Research Articles on PLK4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with PLK4 blocking peptide
Pathways associated with PLK4 blocking peptide
Diseases associated with PLK4 blocking peptide
Organs/Tissues associated with PLK4 blocking peptide
|