NP_068590.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,634 Da
NCBI Official Full Name
protein salvador homolog 1
NCBI Official Synonym Full Names
salvador family WW domain containing protein 1
NCBI Protein Information
protein salvador homolog 1
UniProt Protein Name
Protein salvador homolog 1
UniProt Synonym Protein Names
45 kDa WW domain protein; hWW45
UniProt Synonym Gene Names
UniProt Entry Name
SAV1_HUMAN
NCBI Summary for SAV1
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]
UniProt Comments for SAV1
SAV1: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Homodimer. Stabilized through interaction with STK3/MST2 or STK4/MST1. Interacts (via SARAH domain) with isoform 1 of NEK2. Interacts with ESR1 only in the presence of STK3/MST2. Interacts with WTIP and AJUBA. Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta and interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the adult heart. Expressed in various cell lines.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 14q13-q23
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: protein binding
Biological Process: hair follicle development; keratinocyte differentiation; negative regulation of cardiac muscle cell proliferation; negative regulation of epithelial cell proliferation; positive regulation of apoptosis; positive regulation of fat cell differentiation; positive regulation of transcription factor activity; protein stabilization
Research Articles on SAV1
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Products associated with SAV1 blocking peptide
Pathways associated with SAV1 blocking peptide
Diseases associated with SAV1 blocking peptide
Organs/Tissues associated with SAV1 blocking peptide
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