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Sin1 peptide

Scan QR to view Datasheet Catalog #    MBS843763 Sin1 peptide
Unit / Price
0.05 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Sin1, Peptide

 Also Known As   

Sin1 Blocking Peptide

 Product Gene Name   

Sin1 peptide

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Form/Format    50 ug (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Appearance: Colorless liquid
 Concentration    0.5 mg/ml (lot specific)
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 Handling    The peptide solution should be gently mixed before use.
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 Preparation and Storage    At -20 degree C
Shelf Life: 12 months
 Other Notes    Small volumes of Sin1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for Sin1 peptide   

Western Blot (WB)

 Application Notes for Sin1 peptide    The peptide is used for blocking the antibody activity of Sin1. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37 degree C.
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NCBI/Uniprot data below describe general gene information for Sin1. It may not necessarily be applicable to this product.
 NCBI GI #    28893485
 NCBI GeneID    227743
 NCBI Accession #    NP_796319 [Other Products]
 NCBI GenBank Nucleotide #    NM_177345.4 [Other Products]
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 UniProt Secondary Accession #    Q80UY4; Q8BMV5; Q8R2N9; A2AN72; A2AN74; A2AR13; A2AR16 [Other Products]
 UniProt Related Accession #    Q8BKH7 [Other Products]
 Molecular Weight    37,303 Da
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 NCBI Official Full Name    target of rapamycin complex 2 subunit MAPKAP1 isoform a
 NCBI Official Synonym Full Names    mitogen-activated protein kinase associated protein 1
 NCBI Official Symbol    Mapkap1 [Similar Products]
 NCBI Official Synonym Symbols   
Sin1; AI591529; D230039K05Rik
[Similar Products]
 NCBI Protein Information    target of rapamycin complex 2 subunit MAPKAP1
 UniProt Protein Name    Target of rapamycin complex 2 subunit MAPKAP1
 UniProt Synonym Protein Names   
Mitogen-activated protein kinase 2-associated protein 1; Stress-activated map kinase-interacting protein 1; SAPK-interacting protein 1
 Protein Family    Stress-activated map kinase-interacting protein
 UniProt Gene Name    Mapkap1 [Similar Products]
 UniProt Synonym Gene Names    Mip1; Sin1; TORC2 subunit MAPKAP1; SAPK-interacting protein 1 [Similar Products]
 UniProt Entry Name    SIN1_MOUSE
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 UniProt Comments for Sin1    Sin1: a member of a conserved family of proteins that have an essential roles in signal transduction from yeast to mammals. An essential component of the mTORC2 complex, which consists of mTOR, LST8, Sin1, Protor (PRR5), and RICTOR, the Rapamycin Insensitive Companion of mTOR. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 regulates the phosphorylation of SGK1 S422 and PKCA S657. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Contains a Ras-binding (RBD) and a pleckstrin homology (PH) domains. Plays an important role in the SAPK signaling pathway by binding directly to both ATF-2 and p38. A genetic knockout of Sin1 abolished Akt-S473 phosphorylation and disrupts the RICTOR-mTOR interaction, but Akt-Thr308 phosphorylation is maintained. Six alternatively-spliced isoforms of the human protein have been reported. All isoforms except 4 can be incorporated into the the mTORC2 complex.

Protein type: Adaptor/scaffold

Cellular Component: nucleoplasm; Golgi apparatus; membrane; cytoplasm; plasma membrane; cytoplasmic vesicle; nucleus

Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; Ras GTPase binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein kinase binding

Biological Process: negative regulation of Ras protein signal transduction
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 Research Articles on Sin1    1. data suggest that DNA-PKcs-SIN1 complexation-mediated Akt activation (Ser-473 phosphorylation) is required for mouse osteoblast differentiation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Sin1 peptideDiseases associated with Sin1 peptide
 Reference Product  PubMed Publications
 Mtor peptide  >27 publications with Sin1 and Mtor
 Rictor peptide  >17 publications with Sin1 and Rictor
 Rptor peptide  >6 publications with Sin1 and Rptor
 Mlst8 peptide  >6 publications with Sin1 and Mlst8
 Akt1 peptide  >2 publications with Sin1 and Akt1
 Prkdc peptide  >1 publications with Sin1 and Prkdc
 Eif4ebp1 peptide  >1 publications with Sin1 and Eif4ebp1
 Akt1s1 peptide  >1 publications with Sin1 and Akt1s1
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >7 publications with Sin1 and Necrosis
 Carcinoma Antibodies  >6 publications with Sin1 and Carcinoma
 Inflammation Antibodies  >5 publications with Sin1 and Inflammation
 Liver Neoplasms Antibodies  >3 publications with Sin1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with Sin1 and Carcinoma, Hepatocellular
 Lung Diseases Antibodies  >3 publications with Sin1 and Lung Diseases
 Adenocarcinoma Antibodies  >3 publications with Sin1 and Adenocarcinoma
 Lung Neoplasms Antibodies  >3 publications with Sin1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >2 publications with Sin1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with Sin1 and Neoplasms, Experimental
Organs/Tissues associated with Sin1 peptide
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with Sin1 and Lung
 Kidney Antibodies  >3 publications with Sin1 and Kidney
 Liver Antibodies  >3 publications with Sin1 and Liver
 Skin Antibodies  >2 publications with Sin1 and Skin
 Brain Antibodies  >2 publications with Sin1 and Brain
 Eye Antibodies  >1 publications with Sin1 and Eye
 Muscle Antibodies  >1 publications with Sin1 and Muscle
 Testis Antibodies  >1 publications with Sin1 and Testis
 Heart Antibodies  >1 publications with Sin1 and Heart
 Bone Marrow Antibodies  >1 publications with Sin1 and Bone Marrow
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