NP_005217.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,250 Da
NCBI Official Full Name
sphingosine 1-phosphate receptor 3
NCBI Official Synonym Full Names
sphingosine-1-phosphate receptor 3
NCBI Protein Information
sphingosine 1-phosphate receptor 3; S1P receptor 3; S1P receptor EDG3; S1P receptor Edg-3; sphingosine 1-phosphate receptor Edg-3; endothelial differentiation G-protein coupled receptor 3; G protein-coupled receptor, endothelial differentiation gene-3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
UniProt Protein Name
Sphingosine 1-phosphate receptor 3
UniProt Synonym Protein Names
Endothelial differentiation G-protein coupled receptor 3; Sphingosine 1-phosphate receptor Edg-3
UniProt Synonym Gene Names
UniProt Entry Name
S1PR3_HUMAN
NCBI Summary for EDG-3
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]
UniProt Comments for EDG-3
Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Ref.9
Subcellular location: Cell membrane; Multi-pass membrane protein.
Tissue specificity: Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Research Articles on EDG-3
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Products associated with EDG-3 peptide
Pathways associated with EDG-3 peptide
Diseases associated with EDG-3 peptide
Organs/Tissues associated with EDG-3 peptide
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