NP_005616.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,762 Da
NCBI Official Full Name
syntenin-1 isoform 1
NCBI Official Synonym Full Names
syndecan binding protein
NCBI Official Synonym Symbols
ST1; MDA9; SYCL; MDA-9; TACIP18 [Similar Products]
NCBI Protein Information
syntenin-1
UniProt Protein Name
Syntenin-1
UniProt Synonym Protein Names
Melanoma differentiation-associated protein 9; MDA-9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; TACIP18; Scaffold protein Pbp1; Syndecan-binding protein 1
UniProt Synonym Gene Names
UniProt Entry Name
SDCB1_HUMAN
NCBI Summary for SDCBP
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for SDCBP
syntenin: Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cytokine; Vesicle; Cell adhesion; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 8q12
Cellular Component: adherens junction; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum membrane; extracellular space; focal adhesion; interleukin-5 receptor complex; lipid raft; melanosome; membrane; nucleus; plasma membrane
Molecular Function: cell adhesion molecule binding; cytoskeletal adaptor activity; ephrin receptor binding; frizzled binding; glycoprotein binding; growth factor binding; identical protein binding; interleukin-5 receptor binding; neurexin binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity; protein N-terminus binding; syndecan binding
Biological Process: actin cytoskeleton organization and biogenesis; ephrin receptor signaling pathway; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of receptor internalization; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of JNK cascade; positive regulation of phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; protein targeting to membrane; Ras protein signal transduction; regulation of mitotic cell cycle; substrate-bound cell migration, cell extension; synaptic transmission
Research Articles on SDCBP
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Products associated with SDCBP blocking peptide
Pathways associated with SDCBP blocking peptide
Diseases associated with SDCBP blocking peptide
Organs/Tissues associated with SDCBP blocking peptide
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