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TRPM7 peptide :: TRPM7 / LTRPC7 Peptide

Scan QR to view Datasheet Catalog #    MBS425263 TRPM7 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TRPM7 / LTRPC7, Peptide

 Also Known As   

TRPM7 / LTRPC7 Immunizing Peptide

 Product Synonym Names    TRPM7; transient receptor potential cation channel, subfamily M, member 7; CHAK; CHAK1; LTRPC7; FLJ20117; TRP-PLIK; LTRPC ion channel family member 7; homolog of mouse transient receptor potential-phospholipase C-interacting kinase CHaK hypothetical prote; TRPM7 / LTRPC7
 Product Gene Name   

TRPM7 peptide

[Similar Products]
 Product Synonym Gene Name    LTRPC7 [Similar Products]
 Antibody/Peptide Pairs    TRPM7 / LTRPC7 peptide (MBS425263) is used for blocking the activity of TRPM7/LTRPC7 antibody (MBS421513)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-TKESESTN SVRLML
 OMIM    105500
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 Species Reactivity    Human, Mouse, Rat, Dog, Pig
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of TRPM7 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for TRPM7. It may not necessarily be applicable to this product.
 NCBI GI #    148612863
 NCBI GeneID    54822
 NCBI Accession #    NP_060142.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_017672.5 [Other Products]
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 UniProt Secondary Accession #    Q6ZMF5; Q86VJ4; Q8NBW2; Q9BXB2; Q9NXQ2 [Other Products]
 UniProt Related Accession #    Q96QT4 [Other Products]
 Molecular Weight    212,697 Da
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 NCBI Official Full Name    transient receptor potential cation channel subfamily M member 7 isoform a
 NCBI Official Synonym Full Names    transient receptor potential cation channel subfamily M member 7
 NCBI Official Symbol    TRPM7 [Similar Products]
 NCBI Official Synonym Symbols   
CHAK; CHAK1; ALSPDC; LTRPC7; LTrpC-7; TRP-PLIK
[Similar Products]
 NCBI Protein Information    transient receptor potential cation channel subfamily M member 7
 UniProt Protein Name    Transient receptor potential cation channel subfamily M member 7
 UniProt Synonym Protein Names   
Channel-kinase 1; Long transient receptor potential channel 7; LTrpC-7; LTrpC7
 Protein Family    Transient receptor potential cation channel subfamily
 UniProt Gene Name    TRPM7 [Similar Products]
 UniProt Synonym Gene Names    CHAK1; LTRPC7; LTrpC-7; LTrpC7 [Similar Products]
 UniProt Entry Name    TRPM7_HUMAN
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 NCBI Summary for TRPM7    The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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 UniProt Comments for TRPM7    ChaK1: is an unusual and ubiquitous bifunctional protein containing a transient receptor potential (TRP) ion channel fused to a protein kinase of the Atypical alpha group. Required for early embryonic development and for maintaining cardiac automaticity. The channel conducts Zn(2+), Mg(2+), and Ca(2+) as well as monovalent cations. The kinase can be cleaved from the channel domain. The cleaved kinase translocates to the nucleus where it binds chromatin-remodeling complexes including Polycomb, and phosphorylates specific histone residues. The kinase activity is essential for the channel function, and channel function is critical to maintain physiological intracellular magnesium levels. Plays a key role in oxidative stress-induced cell death. TRP voltage-independent calcium-permeable cation channels are divided into six subfamilies, two of which (TRPC and TRPM) have members that are widely expressed and activated by oxidative stress. Is activated by reactive oxygen/nitrogen species, resulting in cation conductance and anoxic neuronal cell death. This phenotype is rescued by suppression of ChaK1 expression. Related to ChaK2, another Atypical alpha kinase fused to a TRP ion channel protein.

Protein type: Membrane protein, multi-pass; EC 2.7.11.1; Channel, cation; Kinase, protein; Protein kinase, atypical; Membrane protein, integral; ATYPICAL group; Alpha family; ChaK subfamily

Chromosomal Location of Human Ortholog: 15q21

Cellular Component: integral to membrane; plasma membrane; ruffle

Molecular Function: actin binding; ATP binding; calcium channel activity; metal ion binding; myosin binding; protein serine/threonine kinase activity

Biological Process: actomyosin structure organization and biogenesis; calcium-dependent cell-matrix adhesion; protein amino acid autophosphorylation; protein tetramerization

Disease: Amyotrophic Lateral Sclerosis-parkinsonism/dementia Complex 1
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 Research Articles on TRPM7    1. TRPM7 inhibition by siRNA caused an increase in adhesion relative to control, but a decrease to 80% of calcium response relative to non-targeting siRNA which confirms the important role of TRPM7 in mechanotransduction despite the increase in adhesion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TRPM7 peptideDiseases associated with TRPM7 peptide
 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 TRP Channels Pathway antibodies  TRP Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >63 publications with TRPM7 and Cardiovascular Diseases
 Hypertension Antibodies  >28 publications with TRPM7 and Hypertension
 Fibrosis Antibodies  >24 publications with TRPM7 and Fibrosis
 Inflammation Antibodies  >18 publications with TRPM7 and Inflammation
 Kidney Diseases Antibodies  >14 publications with TRPM7 and Kidney Diseases
 Necrosis Antibodies  >11 publications with TRPM7 and Necrosis
 Atherosclerosis Antibodies  >7 publications with TRPM7 and Atherosclerosis
 AMYOTROPHIC LATERAL SCLEROSIS-PARKINSONISM/DEMENTIA COMPLEX 1 Antibodies  >6 publications with TRPM7 and AMYOTROPHIC LATERAL SCLEROSIS-PARKINSONISM/DEMENTIA COMPLEX 1
 Arrhythmias, Cardiac Antibodies  >6 publications with TRPM7 and Arrhythmias, Cardiac
 Edema Antibodies  >4 publications with TRPM7 and Edema
Organs/Tissues associated with TRPM7 peptide
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >70 publications with TRPM7 and Blood
 Muscle Antibodies  >69 publications with TRPM7 and Muscle
 Kidney Antibodies  >65 publications with TRPM7 and Kidney
 Brain Antibodies  >63 publications with TRPM7 and Brain
 Vascular Antibodies  >49 publications with TRPM7 and Vascular
 Heart Antibodies  >38 publications with TRPM7 and Heart
 Bone Antibodies  >29 publications with TRPM7 and Bone
 Intestine Antibodies  >21 publications with TRPM7 and Intestine
 Nerve Antibodies  >18 publications with TRPM7 and Nerve
 Lung Antibodies  >18 publications with TRPM7 and Lung
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