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TSHR peptide

Scan QR to view Datasheet Catalog #    MBS427575 TSHR peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TSHR, Peptide

★Popular Item★
 Also Known As   

TSHR Immunizing Peptide

 Product Synonym Names    TSHR; thyroid stimulating hormone receptor; CHNG1; LGR3; MGC75129; hTSHR-I; TSH-R; seven transmembrane helix receptor; thyroid-stimulating hormone receptor; thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; TSHR (aa101-115)
 Product Gene Name   

TSHR peptide

[Similar Products]
 Product Synonym Gene Name    TSHR [Similar Products]
 Antibody/Peptide Pairs    TSHR peptide (MBS427575) is used for blocking the activity of TSHR antibody (MBS422637)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-SKVTHIEI RNTRNLT
 OMIM    275200
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 Species Reactivity    Human, Cow
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 Supplied As    100 ug of Lyophilized peptide, formulation 5pmol/uL in 5% (v/v) acetonitrile/H2O.Reconstitute pellet in distilled water where required water where required. For blocking studies, reconstitute pellet in 200 uL distilled water to obtain a 0.5 mg/ml peptide solution.
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 Preparation and Storage    Shipped at ambient temperature, store at -20C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of TSHR peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Application Notes for TSHR peptide    The peptide was used in the production of Goat Anti-TSHR (aa101-115) Antibody. It is currently untested in blocking applications.
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NCBI/Uniprot data below describe general gene information for TSHR. It may not necessarily be applicable to this product.
 NCBI GI #    64085121
 NCBI GeneID    7253
 NCBI Accession #    NP_000360.2 [Other Products]
 NCBI Related Accession #    NP_001018046.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000369.2 [Other Products]
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 UniProt Secondary Accession #    Q16503; Q8TB90; Q96GT6; Q9P1V4; Q9ULA3; Q9UPH3; A0PJU7; F5GYU5; G3V2A9 [Other Products]
 UniProt Related Accession #    P16473 [Other Products]
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 NCBI Official Full Name    thyrotropin receptor isoform 1
 NCBI Official Synonym Full Names    thyroid stimulating hormone receptor
 NCBI Official Symbol    TSHR [Similar Products]
 NCBI Official Synonym Symbols   
LGR3; CHNG1; hTSHR-I
[Similar Products]
 NCBI Protein Information    thyrotropin receptor
 UniProt Protein Name    Thyrotropin receptor
 UniProt Synonym Protein Names   
Thyroid-stimulating hormone receptor; TSH-R
 Protein Family    Thyrotropin receptor
 UniProt Gene Name    TSHR [Similar Products]
 UniProt Synonym Gene Names    LGR3; TSH-R [Similar Products]
 UniProt Entry Name    TSHR_HUMAN
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 NCBI Summary for TSHR    The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
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 UniProt Comments for TSHR    TSHR: Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5). Defects in TSHR are found in patients affected by hyperthyroidism with different etiologies. Somatic, constitutively activating TSHR mutations and/or constitutively activating G(s)alpha mutations have been identified in toxic thyroid nodules (TTNs) that are the predominant cause of hyperthyroidism in iodine deficient areas. These mutations lead to TSH independent activation of the cAMP cascade resulting in thyroid growth and hormone production. TSHR mutations are found in autonomously functioning thyroid nodules (AFTN), toxic multinodular goiter (TMNG) and hyperfunctioning thyroid adenomas (HTA). TMNG encompasses a spectrum of different clinical entities, ranging from a single hyperfunctioning nodule within an enlarged thyroid, to multiple hyperfunctioning areas scattered throughout the gland. HTA are discrete encapsulated neoplasms characterized by TSH- independent autonomous growth, hypersecretion of thyroid hormones, and TSH suppression. Defects in TSHR are also a cause of thyroid neoplasms (papillary and follicular cancers). Autoantibodies against TSHR are directly responsible for the pathogenesis and hyperthyroidism of Graves disease. Antibody interaction with TSHR results in an uncontrolled receptor stimulation. Defects in TSHR are the cause of congenital hypothyroidism non-goitrous type 1 (CHNG1); also known as congenital hypothyroidism due to TSH resistance. CHNG1 is a non-autoimmune condition characterized by resistance to thyroid- stimulating hormone (TSH) leading to increased levels of plasma TSH and low levels of thyroid hormone. CHNG1 presents variable severity depending on the completeness of the defect. Most patients are euthyroid and asymptomatic, with a normal sized thyroid gland. Only a subset of patients develop hypothyroidism and present a hypoplastic thyroid gland. Defects in TSHR are the cause of familial gestational hyperthyroidism (HTFG). HTFG is a condition characterized by abnormally high levels of serum thyroid hormones occurring during early pregnancy. Defects in TSHR are the cause of hyperthyroidism non- autoimmune (HTNA). It is a condition characterized by abnormally high levels of serum thyroid hormones, thyroid hyperplasia, goiter and lack of anti-thyroid antibodies. Typical features of Graves disease such as exophthalmia, myxedema, antibodies anti-TSH receptor and lymphocytic infiltration of the thyroid gland are absent. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 14q31

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: peptide receptor activity, G-protein coupled; protein binding; thyroid-stimulating hormone receptor activity

Biological Process: adenylate cyclase activation; cell-cell signaling; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; hormone-mediated signaling; nervous system development; positive regulation of cell proliferation

Disease: Hyperthyroidism, Familial Gestational; Hyperthyroidism, Nonautoimmune; Hypothyroidism, Congenital, Nongoitrous, 1
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 Research Articles on TSHR    1. TSHR gene variants are associated with congenital hypothyroidism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TSHR peptidePathways associated with TSHR peptide
 Reference Product  PubMed Publications
 GNAS peptide  >18 publications with TSHR and GNAS
 NKX2-1 peptide  >14 publications with TSHR and NKX2-1
 TSHB peptide  >8 publications with TSHR and TSHB
 LHCGR peptide  >6 publications with TSHR and LHCGR
 ADRB2 peptide  >5 publications with TSHR and ADRB2
 CGA peptide  >4 publications with TSHR and CGA
 STAT3 peptide  >4 publications with TSHR and STAT3
 GNAQ peptide  >1 publications with TSHR and GNAQ
 Products by Pathway  Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Hormone Ligand-binding Receptors Pathway antibodies  Hormone Ligand-binding Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with TSHR peptideOrgans/Tissues associated with TSHR peptide
 Disease Name  Pubmed Publications
 Hyperthyroidism Antibodies  >532 publications with TSHR and Hyperthyroidism
 Graves Disease Antibodies  >499 publications with TSHR and Graves Disease
 Thyroid Neoplasms Antibodies  >182 publications with TSHR and Thyroid Neoplasms
 Thyroiditis, Autoimmune Antibodies  >116 publications with TSHR and Thyroiditis, Autoimmune
 Carcinoma Antibodies  >115 publications with TSHR and Carcinoma
 Disease Models, Animal Antibodies  >91 publications with TSHR and Disease Models, Animal
 Congenital Hypothyroidism Antibodies  >88 publications with TSHR and Congenital Hypothyroidism
 Adenoma Antibodies  >52 publications with TSHR and Adenoma
 Thyrotoxicosis Antibodies  >45 publications with TSHR and Thyrotoxicosis
 Kidney Diseases Antibodies  >41 publications with TSHR and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >1137 publications with TSHR and Thyroid
 Blood Antibodies  >364 publications with TSHR and Blood
 Ovary Antibodies  >81 publications with TSHR and Ovary
 Connective Tissue Antibodies  >63 publications with TSHR and Connective Tissue
 Muscle Antibodies  >48 publications with TSHR and Muscle
 Brain Antibodies  >36 publications with TSHR and Brain
 Thymus Antibodies  >16 publications with TSHR and Thymus
 Lung Antibodies  >11 publications with TSHR and Lung
 Embryonic Tissue Antibodies  >6 publications with TSHR and Embryonic Tissue
 Placenta Antibodies  >3 publications with TSHR and Placenta
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