NP_006280.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
269,767 Da
NCBI Official Full Name
talin-1
NCBI Official Synonym Full Names
talin 1
NCBI Official Synonym Symbols
NCBI Protein Information
talin-1
UniProt Protein Name
Talin-1
UniProt Synonym Gene Names
UniProt Entry Name
TLN1_HUMAN
NCBI Summary for TLN1
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]
UniProt Comments for TLN1
Talin-1: a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 9p13
Cellular Component: cell surface; cytoplasm; cytosol; extracellular region; focal adhesion; intercellular junction; microtubule organizing center; plasma membrane; ruffle
Molecular Function: actin filament binding; integrin binding; LIM domain binding; protein binding; structural constituent of cytoskeleton; vinculin binding
Biological Process: cell motility; cell-substrate junction assembly; cortical actin cytoskeleton organization and biogenesis; cytoskeletal anchoring; intercellular junction assembly; muscle contraction; platelet degranulation; viral reproduction
Research Articles on TLN1
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Products associated with TLN1 blocking peptide
Pathways associated with TLN1 blocking peptide
Diseases associated with TLN1 blocking peptide
Organs/Tissues associated with TLN1 blocking peptide
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