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Trem2 peptide

Scan QR to view Datasheet Catalog #    MBS425613 Trem2 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Trem2, Peptide

 Also Known As   

Trem2 Immunizing Peptide

 Product Synonym Names    Trem2; triggering receptor expressed on myeloid cells 2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expressed on myeloid cells 2b; triggering receptor expressed on myeloid cells 2c; Trem2 (mouse)
 Product Gene Name   

Trem2 peptide

[Similar Products]
 Antibody/Peptide Pairs    Trem2 peptide (MBS425613) is used for blocking the activity of Trem2 antibody (MBS422239)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-QVEHSTSR NQET
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 Species Reactivity    Mouse, Rat
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of Trem2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Trem2. It may not necessarily be applicable to this product.
 NCBI GI #    13994125
 NCBI GeneID    83433
 NCBI Accession #    NP_112544.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_031254.3 [Other Products]
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 UniProt Secondary Accession #    Q8CGK4; Q8CIA6; Q99NH9; Q9JL34 [Other Products]
 UniProt Related Accession #    Q99NH8 [Other Products]
 Molecular Weight    27,304 Da
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 NCBI Official Full Name    triggering receptor expressed on myeloid cells 2 isoform 1
 NCBI Official Synonym Full Names    triggering receptor expressed on myeloid cells 2
 NCBI Official Symbol    Trem2 [Similar Products]
 NCBI Official Synonym Symbols   
TREM-2; Trem2a; Trem2b; Trem2c
[Similar Products]
 NCBI Protein Information    triggering receptor expressed on myeloid cells 2
 UniProt Protein Name    Triggering receptor expressed on myeloid cells 2
 UniProt Synonym Protein Names   
Triggering receptor expressed on monocytes 2
 Protein Family    Triggering receptor expressed on myeloid cells
 UniProt Gene Name    Trem2 [Similar Products]
 UniProt Synonym Gene Names    Trem2a; Trem2b; Trem2c; TREM-2 [Similar Products]
 UniProt Entry Name    TREM2_MOUSE
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 NCBI Summary for Trem2    The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
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 UniProt Comments for Trem2    TREM2: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: extracellular region; integral to membrane; intracellular membrane-bound organelle; membrane; plasma membrane

Molecular Function: lipopolysaccharide binding; peptidoglycan binding; protein binding; transmembrane receptor activity

Biological Process: detection of lipopolysaccharide; detection of peptidoglycan; innate immune response; lipopolysaccharide-mediated signaling pathway; phagocytosis, engulfment; positive regulation of antigen processing and presentation of peptide antigen via MHC class II; positive regulation of calcium-mediated signaling; positive regulation of peptidyl-tyrosine phosphorylation
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 Research Articles on Trem2    1. TREM2 is involved in prion-induced microglial activation but does not noticeably modulate the pathogenesis of experimental prion infections.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Trem2 peptidePathways associated with Trem2 peptide
 Reference Product  PubMed Publications
 Tyrobp peptide  >75 publications with Trem2 and Tyrobp
 Syk peptide  >8 publications with Trem2 and Syk
 Plxna1 peptide  >3 publications with Trem2 and Plxna1
 Sema6d peptide  >1 publications with Trem2 and Sema6d
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
Diseases associated with Trem2 peptideOrgans/Tissues associated with Trem2 peptide
 Disease Name  Pubmed Publications
 Dementia Antibodies  >140 publications with Trem2 and Dementia
 Alzheimer Disease Antibodies  >113 publications with Trem2 and Alzheimer Disease
 Inflammation Antibodies  >71 publications with Trem2 and Inflammation
 Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy Antibodies  >29 publications with Trem2 and Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
 Disease Models, Animal Antibodies  >27 publications with Trem2 and Disease Models, Animal
 Necrosis Antibodies  >17 publications with Trem2 and Necrosis
 Lung Diseases Antibodies  >13 publications with Trem2 and Lung Diseases
 Memory Disorders Antibodies  >8 publications with Trem2 and Memory Disorders
 Cognition Disorders Antibodies  >7 publications with Trem2 and Cognition Disorders
 Cardiovascular Diseases Antibodies  >7 publications with Trem2 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >123 publications with Trem2 and Brain
 Blood Antibodies  >43 publications with Trem2 and Blood
 Lung Antibodies  >18 publications with Trem2 and Lung
 Bone Marrow Antibodies  >13 publications with Trem2 and Bone Marrow
 Spinal Cord Antibodies  >8 publications with Trem2 and Spinal Cord
 Joint Antibodies  >4 publications with Trem2 and Joint
 Mixed Antibodies  >3 publications with Trem2 and Mixed
 Skin Antibodies  >2 publications with Trem2 and Skin
 Embryonic Tissue Antibodies  >1 publications with Trem2 and Embryonic Tissue
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