NP_065816.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,957 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase UBR4
NCBI Official Synonym Full Names
ubiquitin protein ligase E3 component n-recognin 4
NCBI Protein Information
E3 ubiquitin-protein ligase UBR4
UniProt Protein Name
E3 ubiquitin-protein ligase UBR4
UniProt Synonym Protein Names
600 kDa retinoblastoma protein-associated factor; N-recognin-4; Retinoblastoma-associated factor of 600 kDa; RBAF600; p600; Zinc finger UBR1-type protein 1
UniProt Synonym Gene Names
UniProt Entry Name
UBR4_HUMAN
NCBI Summary for UBR4
The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]
UniProt Comments for UBR4
UBR4: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Belongs to the UBR4 family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; Ubiquitin conjugating system; Ligase; EC 6.3.2.19; EC 6.3.2.-; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36.13
Cellular Component: centrosome; cytoplasm; integral to membrane; membrane; nucleoplasm
Molecular Function: calmodulin binding; ligase activity; protein binding; ubiquitin-protein ligase activity; zinc ion binding
Biological Process: protein ubiquitination during ubiquitin-dependent protein catabolic process; viral reproduction
Research Articles on UBR4
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Products associated with UBR4 blocking peptide
Pathways associated with UBR4 blocking peptide
Diseases associated with UBR4 blocking peptide
Organs/Tissues associated with UBR4 blocking peptide
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